@article{fdi:010049954,
  title = {{C}o-infection with {O}nchocerca volvulus and {L}oa loa microfilariae in central {C}ameroon : are these two species interacting},
  author = {{P}ion, {S}{\'e}bastien and {C}larke, {P}. and {F}ilipe, {J}.{A}.{N}. and {K}amgno, {J}. and {G}ardon, {J}acques and {B}asanez, {M}.{G}. and {B}oussinesq, {M}ichel},
  editor = {},
  language = {{ENG}},
  abstract = {{I}vermectin treatment may induce severe adverse reactions in some individuals heavily infected with {L}oa loa. {T}his hampers the implementation of mass ivermectin treatment against onchocerciasis in areas where {O}nchocerca volvulus and {L}. loa are co-endemic. {I}n order to identify factors, including co-infections, which may explain the presence of high {L}. loa micro-filaraemia in some individuals, we analysed data collected in 19 villages of central {C}ameroon. {T}wo standardized skin snips and 30 mu l of blood were obtained from each of 3190 participants and the microfilarial (mf) loads of both {O}. volvulus and {L}. loa were quantified. {T}he data were analysed using multivariate hierarchical models. {I}ndividual-level variables were: age, sex, mf presence, and mf load; village-related variables included the endemicity levels for each infection. {T}he two species show a certain degree of ecological separation in the study area. {H}owever, for a given individual host, the presence of microfilariae of one species was positively associated with the presence of microfilariae of the other ({OR} = 1-79, 95 % {CI} [1-43-2-24]). {A}mong individuals harbouring {L}oa microfilariae, there was a slight positive relationship between the {L}. loa and {O}. volvulus mf loads which corresponded to an 11% increase in {L}. loa mf load per 100 {O}. volvulus microfilariae. {C}o-infection with {O}. volvulus is not sufficient to explain the very high {L}. loa mf loads harboured by some individuals.},
  keywords = {{O}nchocerca volvulus ; {L}oa loa ; {M}icrofilariae ; co infection ; association ; {C}ameroon},
  booktitle = {},
  journal = {{P}arasitology},
  volume = {132},
  numero = {6},
  pages = {843--854},
  ISSN = {0031-1820},
  year = {2006},
  DOI = {1017/{S}003118200600984{X}},
  URL = {https://www.documentation.ird.fr/hor/fdi:010049954},
}