Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Bioinformatics 2636-2638 2008 fdi:010049801 ENG Bioinformatics 1367-4803 ISI:000260976100013 22 10.1093/bioinformatics/btn492 https://www.documentation.ird.fr/hor/fdi:010049801 https://www.documentation.ird.fr/intranet/publi/depot/2010-06-04/010049801.pdf 24 Horizon (IRD) We describe here an exploratory tool, called FunNet, which implements an original systems biology approach, aiming to improve the biological relevance of the modular interaction patterns identified in transcriptional co-expression networks. A suitable analytical model, involving two abstraction layers, has been devised to relate expression profiles to the knowledge on transcripts' biological roles, extracted from genomic databases, into a comprehensive exploratory framework. This approach has been implemented into a user-friendly web tool to promote its open use by the community. 020 UR079