%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Prifti, E.
%A Zucker, Jean-Daniel
%A Clément, K.
%A Henegar, C.
%T FunNet : an integrative tool for exploring transcriptional interactions
%D 2008
%L fdi:010049801
%G ENG
%J Bioinformatics
%@ 1367-4803
%M ISI:000260976100013
%N 22
%P 2636-2638
%R 10.1093/bioinformatics/btn492
%U https://www.documentation.ird.fr/hor/fdi:010049801
%> https://www.documentation.ird.fr/intranet/publi/depot/2010-06-04/010049801.pdf
%V 24
%W Horizon (IRD)
%X We describe here an exploratory tool, called FunNet, which implements an original systems biology approach, aiming to improve the biological relevance of the modular interaction patterns identified in transcriptional co-expression networks. A suitable analytical model, involving two abstraction layers, has been devised to relate expression profiles to the knowledge on transcripts' biological roles, extracted from genomic databases, into a comprehensive exploratory framework. This approach has been implemented into a user-friendly web tool to promote its open use by the community.
%$ 020