@article{fdi:010049724,
  title = {{U}nderstanding the alphaviruses : recent research on important emerging pathogens and progress towards their control},
  author = {{G}ould, {E}. {A}. and {C}outard, {B}. and {M}alet, {H}. and {M}orin, {B}. and {J}amal, {S}. and {W}eaver, {S}. and {G}orbalenya, {A}. and {M}oureau, {G}. and {B}aronti, {C}{\'e}cile and {D}elogu, {I}. and {F}orrester, {N}. and {K}hasnatinov, {M}. and {G}ritsun, {T}. and de {L}amballerie, {X}avier and {C}anard, {B}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he alphaviruses were amongst the first arboviruses to be isolated, characterized and assigned a taxonomic status. {T}hey are globally very widespread, infecting a large variety of terrestrial animals, insects and even fish, and circulate both in the sylvatic and urban/peri-urban environment, causing considerable human morbidity and mortality. {N}evertheless, despite their obvious importance as pathogens, there are currently no effective antiviral drugs with which to treat humans or animals infected by any of these viruses. {T}he {EU}-supported project {VIZIER} ({C}omparative {S}tructural {G}enomics of {V}iral {E}nzymes {I}nvolved in {R}eplication, {FP}6 {P}roject: 2004-511960) was instigated with an ultimate view of contributing to the development of antiviral therapies for {RNA} viruses, including the alphaviruses [{C}outard, {B}., {G}orbalenya, {A}.{E}., {S}nijder, {E}.{J}., {L}eontovich, {A}.{M}., {P}oupon, {A}., {D}e {L}amballerie, {X}., {C}harrel, {R}., {G}ould, {E}.{A}., {G}unther, {S}., {N}order, {H}., {K}lempa, {B}., {B}ourhy, {H}., {R}ohayemj, {J}., {L}'hermite, {E}., {N}ordlund, {P}., {S}tuart, {D}.{I}., {O}wens, {R}.{J}., {G}rimes, {J}.{M}., {T}uckerm, {PA}., {B}olognesi, {M}., {M}attevi, {A}., {C}oll, {M}., {J}ones, {TA}., {A}qvist, {J}., {U}nger, {T}., {H}ilgenfeld, {R}., {B}ricogne, {G}., {N}eyts, {J}., {L}a {C}olla, {P}., {P}uerstinger, {G}., {G}onzalez, {J}.{P}., {L}eroy, {E}., {C}ambillau, {C}., {R}omette, {J}.{L}., {C}anard, {B}., 2008. {T}he {VIZIER} project: preparedness against pathogenic {RNA} viruses. {A}ntiviral {R}es. 78, 37-46]. {T}his review highlights some of the major features of alphaviruses that have been investigated during recent years. {A}fter describing their classification, epidemiology and evolutionary history and the expanding geographic distribution of {C}hikungunya virus, we review progress in understanding the structure and function of alphavirus replicative enzymes achieved under the {VIZIER} programme and the development of new disease control strategies.},
  keywords = {{A}lphavirus ; {G}enomics ; {S}tructure/function studies ; {R}eplicative enzymes ; {A}ntivirals ; {E}volution ; {C}lassification ; {B}iogeography ; {VIZIER}},
  booktitle = {},
  journal = {{A}ntiviral {R}esearch},
  volume = {87},
  numero = {2},
  pages = {111--124},
  ISSN = {0166-3542},
  year = {2010},
  DOI = {10.1016/j.antiviral.2009.07.007},
  URL = {https://www.documentation.ird.fr/hor/fdi:010049724},
}