Longeon A. auteur aut IRD Copp B. R. auteur aut IRD Roué M. auteur aut IRD Dubois J. auteur aut IRD Valentin A. auteur aut IRD Petek Sylvain auteur aut IRD Debitus Cécile auteur aut IRD Bourguet-Kondracki M. L. auteur aut IRD text journalArticle eng text/pdf born digital access Bioassay-directed fractionation of South Pacific marine sponges of the genus Xestospongia has led to the isolation of a number of halenaquinone-type polyketides, including two new derivatives named xestosaprol C methylacetal 7 and orhalquinone 8. Chemical characterization of these two new compounds was achieved by extensive 1D and 2D NMR spectroscopic studies. Evaluation of anti-phospholipase A(2), anti-farnesyltransferase and antiplasmodial activities of this series is presented and structure/activity relationships are discussed. Orhalquinone 8 displayed a significant inhibition of both human and yeast farnesyltransferase enzymes, with IC50 value of 0.40 mu M and was a moderate growth inhibitor of Plasmodium falciparum. specialized Xestospongia Marine sponge Marine natural product Halenaquinone PLA(2) inhibitor FTase inhibitor Antiplasmodial compound 035 052 18 16 6006-6011 2010 0968-0896 https://www.documentation.ird.fr/hor/fdi:010049723 10.1016/j.bmc.2010.06.066 0968-0896 [F B010049723] https://www.documentation.ird.fr/hor/fdi:010049723 https://www.documentation.ird.fr/intranet/publi/2010/09/010049723.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2010-10-01 2017-08-23 fdi:010049723 fre