New bioactive halenaquinone derivatives from South Pacific marine sponges of the genus Xestospongia Longeon, A. Copp, B. R. Roué, M. Dubois, J. Valentin, A. /Petek, Sylvain /Debitus, Cécile Bourguet-Kondracki, M. L. Xestospongia Marine sponge Marine natural product Halenaquinone PLA(2) inhibitor FTase inhibitor Antiplasmodial compound Bioassay-directed fractionation of South Pacific marine sponges of the genus Xestospongia has led to the isolation of a number of halenaquinone-type polyketides, including two new derivatives named xestosaprol C methylacetal 7 and orhalquinone 8. Chemical characterization of these two new compounds was achieved by extensive 1D and 2D NMR spectroscopic studies. Evaluation of anti-phospholipase A(2), anti-farnesyltransferase and antiplasmodial activities of this series is presented and structure/activity relationships are discussed. Orhalquinone 8 displayed a significant inhibition of both human and yeast farnesyltransferase enzymes, with IC50 value of 0.40 mu M and was a moderate growth inhibitor of Plasmodium falciparum. 2010 text https://www.documentation.ird.fr/hor/fdi:010049723 fdi:010049723 Longeon A., Copp B. R., Roué M., Dubois J., Valentin A., Petek Sylvain, Debitus Cécile, Bourguet-Kondracki M. L.. New bioactive halenaquinone derivatives from South Pacific marine sponges of the genus Xestospongia. 2010, 18 (16), 6006-6011 EN