@article{fdi:010049681,
  title = {{N}onstructural {NS}1 proteins of several mosquito-borne {F}lavivirus do not inhibit {TLR}3 signaling},
  author = {{B}aronti, {C}{\'e}cile and {S}ire, {J}. and de {L}amballerie, {X}avier and {Q}uerat, {G}.},
  editor = {},
  language = {{ENG}},
  abstract = {{F}laviviruses are single-stranded positive {RNA} viruses that replicate through double stranded {RNA} (ds{RNA}) intermediates. {T}hese ds{RNA} may be recognized as pathogen-associated molecular patterns by cellular receptors including membrane-bound {T}oll-like receptor 3 ({TLR}3) and cytosolic helicases {RIG}-{I} and {MDA}5. ds{RNA} stimulation results in signaling cascades converging to activation of interferon ({IFN}) regulatory factor 3 ({IRF}3) and to transcriptional activation of several interferon stimulated genes, including {IFN} beta and inflammatory cytokines. {T}here are conflicting reports concerning the ability of {W}est {N}ile virus to counteract {TLR}3 signaling. {I}n our analyses, transiently or stably expressed {NS}1 proteins from two {W}est {N}ile viruses, two dengue 2 viruses and a yellow fever virus failed to inhibit {TLR}3 signaling in two different mammalian cell lines. {M}oreover, using si{RNA} inhibiting the helicase signalization pathway, we show that viral infection did not impede {TLR}3 responses to poly({I}:{C}). {W}e conclude that {NS}1 proteins from distinct mosquito-borne flaviviruses do not inhibit {TLR}3 signaling.},
  keywords = {{F}lavivirus ; {W}est {N}ile virus ; {TLR}3 ; {I}nnate immunity ; {NS}1 ; {I}nterferon},
  booktitle = {},
  journal = {{V}irology},
  volume = {404},
  numero = {2},
  pages = {319--330},
  ISSN = {0042-6822},
  year = {2010},
  DOI = {10.1016/j.virol.2010.05.020},
  URL = {https://www.documentation.ird.fr/hor/fdi:010049681},
}