@article{fdi:010049622,
  title = {{A}nalysis of the mdr-1 gene in patients co-infected with {O}nchocerca volvulus and {L}oa loa who experienced a post-ivermectin serious adverse event},
  author = {{B}ourguinat, {C}. and {K}amgno, {J}. and {B}oussinesq, {M}ichel and {M}ackenzie, {C}. {D}. and {P}richard, {R}. {K}. and {G}eary, {T}. {G}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}vermectin ({IVM}) is exceptionally safe in humans, and is used for mass treatment of onchocerciasis and lymphatic filariasis. {H}owever, cases of encephalopathy, sometimes fatal, have been reported in a small number of individuals who harbored large numbers of {L}ou loa microfilariae (mf). {A} loss-of-function mutation in the mdr-1 gene in some dog breeds and in mice leads to accumulation of the drug in the brain, causing coma and death. {T}his hypothesis was tested in four individuals from {C}ameroon who experienced a post-{IVM} serious adverse event ({SAE}) and in nine non-{SAE} matched controls. {N}o loss-of-function mutation was detected in mdr-1 in any subject. {H}owever, haplotypes, associated with altered drug disposition, were present as homozygotes in two of the {SAE} patients (50%), but absent as homozygotes in the controls (0%). {A}n association of high {L}ou mf load and a genetic predisposition to altered {IVM} distribution could be involved in {IVM} {SAE}s.},
  keywords = {},
  booktitle = {},
  journal = {{A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene},
  volume = {83},
  numero = {1},
  pages = {28--32},
  ISSN = {0002-9637},
  year = {2010},
  DOI = {10.4269/ajtmh.2010.09-0734},
  URL = {https://www.documentation.ird.fr/hor/fdi:010049622},
}