@article{fdi:010049614,
  title = {{H}eritability of the human infectious reservoir of malaria parasites},
  author = {{L}awaly, {Y}. {R}. and {S}akuntabhai, {A}. and {M}arrama, {L}. and {K}onate, {L}. and {P}himpraphi, {W}. and {S}okhna, {C}heikh and {T}all, {A}. and {S}arr, {F}. {D}. and {P}eerapittayamongkol, {C}. and {L}ouicharoen, {C}. and {S}chneider, {B}. {S}. and {L}evescot, {A}. and {T}alman, {A}. and {C}asademont, {I}. and {M}enard, {D}. and {T}rape, {J}ean-{F}rancois and {R}ogier, {C}. and {K}aewkunwal, {J}. and {S}ura, {T}. and {N}uchprayoon, {I}. and {A}riey, {F}. and {B}aril, {L}. and {S}inghasivanon, {P}. and {M}ercereau-{P}uijalon, {O}. and {P}aul, {R}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {S}tudies on human genetic factors associated with malaria have hitherto concentrated on their role in susceptibility to and protection from disease. {I}n contrast, virtually no attention has been paid to the role of human genetics in eliciting the production of parasite transmission stages, the gametocytes, and thus enhancing the spread of disease. {M}ethods and {F}indings: {W}e analysed four longitudinal family-based cohort studies from {S}enegal and {T}hailand followed for 2-8 years and evaluated the relative impact of the human genetic and non-genetic factors on gametocyte production in infections of {P}lasmodium falciparum or {P}. vivax. {P}revalence and density of gametocyte carriage were evaluated in asymptomatic and symptomatic infections by examination of {G}iemsa-stained blood smears and/or {RT}-{PCR} (for falciparum in one site). {A} significant human genetic contribution was found to be associated with gametocyte prevalence in asymptomatic {P}. falciparum infections. {B}y contrast, there was no heritability associated with the production of gametocytes for {P}. falciparum or {P}. vivax symptomatic infections. {S}ickle cell mutation, {H}b{S}, was associated with increased gametocyte prevalence but its contribution was small. {C}onclusions: {T}he existence of a significant human genetic contribution to gametocyte prevalence in asymptomatic infections suggests that candidate gene and genome wide association approaches may be usefully applied to explore the underlying human genetics. {P}rospective epidemiological studies will provide an opportunity to generate novel and perhaps more epidemiologically pertinent gametocyte data with which similar analyses can be performed and the role of human genetics in parasite transmission ascertained.},
  keywords = {},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {5},
  numero = {6},
  pages = {e11358},
  ISSN = {1932-6203},
  year = {2010},
  DOI = {10.1371/journal.pone.0011358},
  URL = {https://www.documentation.ird.fr/hor/fdi:010049614},
}