@article{fdi:010049591,
  title = {{R}obertsonian fusions, pericentromeric repeat organization and evolution : a case study within a highly polymorphic rodent species, {G}erbillus nigeriae},
  author = {{G}authier, {P}hilippe and {H}ima, {K}armadine and {D}obigny, {G}authier},
  editor = {},
  language = {{ENG}},
  abstract = {{P}ericentromeric repeats have been claimed to mediate centric fusions through heterologous recombination of arrays of tandemly repeated and highly homogenized motifs. {H}owever, mammalian case studies are essentially restricted to pathologic fusions in human, or to the house mouse {R}oberstonian ({R}b) races. {W}e here provide an example in a wild gerbil rodent, {G}erbillus nigeriae, which displays an extensive {R}b polymorphism, with 2n ranging between 2n = 60 and 74. {T}he distribution of two closely related repeats, {GERB}1 and {GERB}2 that were previously isolated by {V}olobouev et al. ({C}hromosoma 104:252-259, 1995) in this {A}frican species, were investigated in the genomes of seven individuals with various diploid numbers. {O}ur results clearly show that {GERB}1 and {GERB}2 are organized in a non-random manner, with {GERB}2 and {GERB}1 being clearly juxtacentromeric and centromeric, respectively. {F}inally, cloning and sequencing revealed that, unlike {GERB}2, {GERB}1 monomers display a more homogeneous organization at both the nucleotide and structural levels. {A}ltogether, our results point toward a pivotal role of {GERB}1 repeats in the mediation of {R}b fusions through heterologous recombination, with some evidence of subsequent loss of repeats after the {R}b fusion during the course of evolution of metacentric elements. {M}oreover, the repeat pattern observed in {G}. nigeriae closely matches the organization and sequence structure of satellite {DNA}s described in human acrocentrics. {C}onsequently, {G}. nigeriae appears as an additional model for the study of repeat evolution and its role in centric fusions and their consequences in mammals.},
  keywords = {chromosome evolution ; satellite {DNA} ; repeat evolution ; centric fusions ; centromere ; {M}uridae ; {G}erbillinae},
  booktitle = {},
  journal = {{C}hromosome {R}esearch},
  volume = {18},
  numero = {4},
  pages = {473--486},
  ISSN = {0967-3849},
  year = {2010},
  DOI = {10.1007/s10577-010-9128-9},
  URL = {https://www.documentation.ird.fr/hor/fdi:010049591},
}