@article{fdi:010049585,
  title = {{H}uman immunodeficiency virus-hepatitis {C} virus co-infection in pregnant women and perinatal transmission to infants in {T}hailand},
  author = {{N}go-{G}iang-{H}uong, {N}icole and {J}ourdain, {G}onzague and {S}irirungsi, {W}. and {D}ecker, {L}uc and {K}hamduang, {W}. and {L}e {C}oeur, {S}ophie and {S}irinontakan, {S}. and {S}omsamai, {R}. and {P}agdi, {K}. and {H}emvuttiphan, {J}. and {M}c{I}ntosh, {K}. and {B}arin, {F}. and {L}allemant, {M}arc},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjectives: {T}he objectives of this study were to assess the prevalence and factors associated with hepatitis {C} virus ({HCV}) infection in human immunodeficiency virus ({HIV})-infected and -uninfected {T}hai pregnant women and the rate of {HCV} transmission to their infants. {P}atients and methods: {S}tudy subjects included 1435 {HIV}-infected pregnant women and their infants, enrolled in a perinatal {HIV} prevention trial, and a control group of 448 {HIV}-uninfected pregnant women. {W}omen were screened for {HCV} antibodies with an enzyme immunoassay. {P}ositive results were confirmed by recombinant immunoblot and {HCV} {RNA} quantification. {I}nfants were tested for {HCV} antibodies at 18 months or for {HCV} {RNA} at between 6 weeks and 6 months. {R}esults: {O}f the {HIV}-infected women, 2.9% were {HCV}-infected compared to 0.5% of {HIV}-uninfected women (p = 0.001). {O}nly history of intravenous drug use was associated with {HCV} infection in {HIV}-infected women. {T}en percent of infants born to co-infected mothers acquired {HCV}. {T}he risk of transmission was associated with a high maternal {HCV} {RNA} (p = 0.012), but not with {HIV}-1 load or {CD}4 count. {C}onclusions: {A}cquisition of {HCV} through intravenous drug use partially explains the higher rate of {HCV} infection in {HIV}-infected {T}hai women than in {HIV}-uninfected controls. {P}erinatal transmission occurred in 10% of infants of {HIV}-{HCV}-co-infected mothers and was associated with high maternal {HCV} {RNA}.},
  keywords = {{HIV} ; {HCV} ; {R}isk factors ; {P}erinatal transmission ; {I}ntravenous drug use ; {T}hailand},
  booktitle = {},
  journal = {{I}nternational {J}ournal of {I}nfectious {D}iseases},
  volume = {14},
  numero = {7},
  pages = {{E}602--{E}607},
  ISSN = {1201-9712},
  year = {2010},
  DOI = {10.1016/j.ijid.2009.09.002},
  URL = {https://www.documentation.ird.fr/hor/fdi:010049585},
}