Marti G. auteur aut IRD Eparvier V. auteur aut IRD Moretti Christian auteur aut IRD Prado S. auteur aut IRD Grellier P. auteur aut IRD Hue N. auteur aut IRD Thoison O. auteur aut IRD Delpech B. auteur aut IRD Gueritte F. auteur aut IRD Litaudon M. auteur aut IRD text journalArticle eng text/pdf born digital access In an effort to find antimalarial drugs, a systematic in vitro evaluation on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) was undertaken on sixty plant extracts collected in French Guiana. The ethyl acetate extract obtained from the root barks of Symphonia globulifera exhibited a strong antiplasmodial activity (97% at 10 mu g/ml). The phytochemical investigation of this extract led to the isolation of nine polycyclic polyprenylated acylphloroglucinol (PPAPs) compounds and two oxidized derivatives. All compounds showed antiplasmodial activity with IC(50)s ranged from 2.1 to 10.1 mu M. A LC/ESI-MSn study performed on polyprenylated benzophenones previously isolated from Moronobea coccinea provided a reliable method for their detection in the extract and structural elucidation. specialized Symphonia globulifera Clusiaceae Benzophenone Symphonone Antiplasmodial LC/ESI-MS 076 71 8-9 964-974 2010 0031-9422 https://www.documentation.ird.fr/hor/fdi:010049583 10.1016/j.phytochem.2010.03.008 0031-9422 [F B010049583] https://www.documentation.ird.fr/hor/fdi:010049583 https://www.documentation.ird.fr/intranet/publi/2010/07-2/010049583.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2010-08-03 2017-08-23 fdi:010049583 fre