@article{fdi:010049583,
  title = {{A}ntiplasmodial benzophenone derivatives from the root barks of {S}ymphonia globulifera ({C}lusiaceae)},
  author = {{M}arti, {G}. and {E}parvier, {V}. and {M}oretti, {C}hristian and {P}rado, {S}. and {G}rellier, {P}. and {H}ue, {N}. and {T}hoison, {O}. and {D}elpech, {B}. and {G}ueritte, {F}. and {L}itaudon, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}n an effort to find antimalarial drugs, a systematic in vitro evaluation on a chloroquine-resistant strain of {P}lasmodium falciparum ({F}c{B}1) was undertaken on sixty plant extracts collected in {F}rench {G}uiana. {T}he ethyl acetate extract obtained from the root barks of {S}ymphonia globulifera exhibited a strong antiplasmodial activity (97% at 10 mu g/ml). {T}he phytochemical investigation of this extract led to the isolation of nine polycyclic polyprenylated acylphloroglucinol ({PPAP}s) compounds and two oxidized derivatives. {A}ll compounds showed antiplasmodial activity with {IC}(50)s ranged from 2.1 to 10.1 mu {M}. {A} {LC}/{ESI}-{MS}n study performed on polyprenylated benzophenones previously isolated from {M}oronobea coccinea provided a reliable method for their detection in the extract and structural elucidation.},
  keywords = {{S}ymphonia globulifera ; {C}lusiaceae ; {B}enzophenone ; {S}ymphonone ; {A}ntiplasmodial ; {LC}/{ESI}-{MS}},
  booktitle = {},
  journal = {{P}hytochemistry},
  volume = {71},
  numero = {8-9},
  pages = {964--974},
  ISSN = {0031-9422},
  year = {2010},
  DOI = {10.1016/j.phytochem.2010.03.008},
  URL = {https://www.documentation.ird.fr/hor/fdi:010049583},
}