@article{fdi:010049483,
  title = {{E}xtensive survey on the prevalence and genetic diversity of {SIV}s in primate bushmeat provides insights into risks for potential new cross-species transmissions},
  author = {{A}ghokeng {F}obang, {A}velin and {A}youba, {A}hidjo and {M}poudi-{N}gole, {E}. and {L}oul, {S}. and {L}i{\'e}geois, {F}lorian and {D}elaporte, {E}ric and {P}eeters, {M}artine},
  editor = {},
  language = {{ENG}},
  abstract = {{T}o evaluate the risk of cross-species transmissions of {SIV}s from non-human primates to humans at the primate/hunter interface, a total of 2586 samples, derived from primate bushmeat representing 11 different primate species, were collected at 6 distinct remote forest sites in southeastern {C}ameroon and in {Y}aounde, the capital city {SIV} prevalences were estimated with an updated {SIV} lineage specific gp41 peptide {ELISA} covering the major part of the {SIV} diversity. {SIV} positive samples were confirmed by {PCR} and sequence analysis of partial pol fragments. {T}he updated {SIV} {ELISA} showed good performance with overall sensitivity and specificity of 96% and 97.5% respectively {T}he overall {S}ly seroprevalence was low, 2.93% (76/2586) and ranged between 0.0% and 5.7% at forest sites, and reached up to 10.3% in {Y}aounde. {S}ly infection was documented in 8 of the 11 species with significantly different prevalence rates per species: 9/859 (10%) in {C}ercopithecus nictitans, 9/864 (1.0%) {C}ercopithecus cephus, 10/60 (16.7%) {M}iopithecus ogouensis, 14/78 (17 9%) {C}olobus guereza, 15/37 (40 5%) {C}ercopithecus neglectus, 10/27 (33 3%) {M}andrillus sphinx, 6/12 (50%) {C}ercocebus torquatus, and 3/6 (50%) {C}hlorocebus tantalus {N}o {SIV} infection was identified in {C}ercopithecus pogomas (n = 293), {L}ophocebus albigena (n = 168) and {C}ercocebus agilis (n = 182) {T}he {SIV} prevalences also seem to vary within species according to the sampling site, but most importantly, the highest {SIV} prevalences are observed in the primate species which represent only 8.5% of the overall primate bushmeat {T}he phylogenetic tree of partial pal sequences illustrates the high genetic diversity of {SIV}s between and within different primate species {T}he tree also showed some interesting features within the {SIV}deb lineage suggesting phylogeographic clusters. {O}verall, the risk for additional cross-species transmissions is not equal throughout southern {C}ameroon and depends on the hunted species and {SIV} prevalences in each species {H}owever, humans are still exposed to a high diversity of {SIV}s as illustrated by the high {I}nter and intra {SIV} lineage genetic diversity.},
  keywords = {{SIV} ; {HIV} ; {AIDS} ; {N}on-human primates ; {P}revalence ; {C}ross-species transmission ; {G}enetic diversity},
  booktitle = {},
  journal = {{I}nfection {G}enetics and {E}volution},
  volume = {10},
  numero = {3},
  pages = {386--396},
  ISSN = {1567-1348},
  year = {2010},
  DOI = {10.1016/j.meegid.2009.04.014},
  URL = {https://www.documentation.ird.fr/hor/fdi:010049483},
}