@article{fdi:010049336,
  title = {{A} controlled trial to assess the effect of quinine, chloroquine, amodiaquine, and artesunate on {L}oa loa {M}icrofilaremia},
  author = {{K}amgno, {J}. and {D}jomo, {P}. {N}. and {P}ion, {S}{\'e}bastien and {T}hylefors, {B}. and {B}oussinesq, {M}ichel},
  editor = {},
  language = {{ENG}},
  abstract = {{O}nchocerciasis control is currently based on mass ivermectin treatment. {U}nfortunately, this drug can induce serious adverse events ({SAE}s) in persons with high levels of {L}oa loa microfilaremia (> 30,000 microfilaria/m{L}). {A} means of preventing {SAE}s would be to treat at risk populations with a drug that would progressively reduce the microfilarial loads before administering ivermectin. {A}ntimalarial drugs are a potential solution because they have shown some activity against various filarial species. {A} controlled trial was conducted to assess the effect of standard doses of quinine, chloroquine, amodiaquine, and artesunate on {L}. {I}on microfilaremia. {N}inety-eight patients were randomly allocated into five groups (one for each drug and a control group) after stratification on microfilarial load. {L}oa loa microfilaremia was monitored on days 0, 3, 7, 15, 30 60, and 90. {N}o significant change in the loads was recorded in any of the treatment groups. {A} comprehensive review of the effects of antimalarial drugs against filariae is also provided.},
  keywords = {},
  booktitle = {},
  journal = {{A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene},
  volume = {82},
  numero = {3},
  pages = {379--385},
  ISSN = {0002-9637},
  year = {2010},
  DOI = {10.4269/ajtmh.2010.09-0573},
  URL = {https://www.documentation.ird.fr/hor/fdi:010049336},
}