@article{fdi:010049329,
  title = {{A} novel sex determination system in a close relative of the house mouse},
  author = {{V}eyrunes, {F}. and {C}hevret, {P}. and {C}atalan, {J}. and {C}astiglia, {R}. and {W}atson, {J}. and {D}obigny, {G}authier and {R}obinson, {T}. {J}. and {B}ritton {D}avidian, {J}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}herian mammals have an extremely conserved {XX}/{XY} sex determination system. {A} limited number of mammal species have, however, evolved to escape convention and present aberrant sex chromosome complements. {I}n this study, we identified a new case of atypical sex determination in the {A}frican pygmy mouse {M}us minutoides, a close evolutionary relative of the house mouse. {T}he pygmy mouse is characterized by a very high proportion of {XY} females (74%, n = 27) from geographically widespread {S}outhern and {E}astern {A}frican populations. {S}equencing of the high mobility group domain of the mammalian sex determining gene {S}ry, and karyological analyses using fluorescence in situ hybridization and {G}-banding data, suggest that the sex reversal is most probably not owing to a mutation of {S}ry, but rather to a chromosomal rearrangement on the {X} chromosome. {I}n effect, two morphologically different {X} chromosomes were identified, one of which, designated {X}*, is invariably associated with sex-reversed females. {T}he asterisk designates the still unknown mutation converting {X}*{Y} individuals into females. {A}lthough relatively still unexplored, such an atypical sex chromosome system offers a unique opportunity to unravel new genetic interactions involved in the initiation of sex determination in mammals.},
  keywords = {{A}frican pygmy mouse ; {M}us minutoides ; atypical sex determination system ; sex-reversed females ; {S}ry gene ; {X}* chromosome},
  booktitle = {},
  journal = {{P}roceedings of the {R}oyal {S}ociety {B} - {B}iological {S}ciences},
  volume = {277},
  numero = {1684},
  pages = {1049--1056},
  ISSN = {0962-8452},
  year = {2010},
  DOI = {10.1098/rspb.2009.1925},
  URL = {https://www.documentation.ird.fr/hor/fdi:010049329},
}