@article{fdi:010049324,
  title = {{A}modiaquine dosage and tolerability for intermittent preventive treatment to prevent malaria in children},
  author = {{C}airns, {M}. and {C}isse, {B}. and {S}okhna, {C}heikh and {C}ames, {C}{\'e}cile and {S}imondon, {K}irsten and {B}a, {E}. {H}. and {T}rape, {J}ean-{F}ran{\c{c}}ois and {G}aye, {O}. and {G}reenwood, {B}. {M}. and {M}illigan, {P}. {J}. {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{S}ulfadoxine-pyrimethamine with amodiaquine ({SP}-{AQ}) is a highly efficacious regimen for intermittent preventive treatment to prevent malaria in children ({IPT}c), but the amodiaquine component is not always well tolerated. {W}e determined the association between amodiaquine dosage by body weight and mild adverse events ({AE}s) and investigated whether alternative age-based regimens could improve dosing accuracy and tolerability, using data from two trials of {IPT}c in {S}enegal, one in which {AQ} dose was determined by age and the other in which it was determined by weight category. {B}oth dosage strategies resulted in some children receiving {AQ} doses above the recommended therapeutic range. {T}he odds of vomiting increased with increasing amodiaquine dosage. {I}n one study, incidence of fever also increased with increasing dosage. {A}nthropometric data from 1,956 children were used to predict the dosing accuracy of existing and optimal alternative regimens. {L}ogistic regression models describing the probability of {AE}s by dosage were used to predict the potential reductions in mild {AE}s for each regimen. {S}imple amendments to current {AQ} dosing schedules based on the child's age could substantially increase dosing accuracy and thus improve the tolerability of {IPT}c using {SP}-amodiaquine in situations where weighing the child is impractical.},
  keywords = {},
  booktitle = {},
  journal = {{A}ntimicrobial {A}gents and {C}hemotherapy},
  volume = {54},
  numero = {3},
  pages = {1265--1274},
  ISSN = {0066-4804},
  year = {2010},
  DOI = {10.1128/aac.01161-09},
  URL = {https://www.documentation.ird.fr/hor/fdi:010049324},
}