%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A White, B. J.
%A Cheng, C. D.
%A Simard, Frédéric
%A Costantini, Carlo
%A Besansky, N. J.
%T Genetic association of physically unlinked islands of genomic divergence in incipient species of Anopheles gambiae
%D 2010
%L fdi:010049274
%G ENG
%J Molecular Ecology
%@ 0962-1083
%K centromeres ; divergent adaptation ; ecological speciation ; malaria vector ; reproductive isolation ; speciation islands
%M ISI:000274550100009
%N 5
%P 925-939
%R 10.1111/j.1365-294X.2010.04531.x
%U https://www.documentation.ird.fr/hor/fdi:010049274
%> https://www.documentation.ird.fr/intranet/publi/2010/02/010049274.pdf
%V 19
%W Horizon (IRD)
%X Previous efforts to uncover the genetic underpinnings of ongoing ecological speciation of the M and S forms of the African malaria vector Anopheles gambiae revealed two centromere-proximal islands of genetic divergence on X and chromosome 2. Under the assumption of considerable ongoing gene flow between M and S, these persistently divergent genomic islands were widely considered to be 'speciation islands'. In the course of microarray-based divergence mapping, we discovered a third centromere-associated island of divergence on chromosome 3, which was validated by targeted re-sequencing. To test for genetic association between the divergence islands on all three chromosomes, SNP-based assays were applied in four natural populations of M and S spanning West, Central and East Africa. Genotyping of 517 female M and S mosquitoes revealed nearly complete linkage disequilibrium between the centromeres of the three independently assorting chromosomes. These results suggest that despite the potential for inter-form gene flow through hybridization, actual (realized) gene flow between M and S may be substantially less than commonly assumed and may not explain most shared variation. Moreover, the possibility of very low gene flow calls into question whether diverged pericentromeric regions-characterized by reduced levels of variation and recombination-are in fact instrumental rather than merely incidental to the speciation process.
%$ 052