@article{fdi:010049274,
  title = {{G}enetic association of physically unlinked islands of genomic divergence in incipient species of {A}nopheles gambiae},
  author = {{W}hite, {B}. {J}. and {C}heng, {C}. {D}. and {S}imard, {F}r{\'e}d{\'e}ric and {C}ostantini, {C}arlo and {B}esansky, {N}. {J}.},
  editor = {},
  language = {{ENG}},
  abstract = {{P}revious efforts to uncover the genetic underpinnings of ongoing ecological speciation of the {M} and {S} forms of the {A}frican malaria vector {A}nopheles gambiae revealed two centromere-proximal islands of genetic divergence on {X} and chromosome 2. {U}nder the assumption of considerable ongoing gene flow between {M} and {S}, these persistently divergent genomic islands were widely considered to be 'speciation islands'. {I}n the course of microarray-based divergence mapping, we discovered a third centromere-associated island of divergence on chromosome 3, which was validated by targeted re-sequencing. {T}o test for genetic association between the divergence islands on all three chromosomes, {SNP}-based assays were applied in four natural populations of {M} and {S} spanning {W}est, {C}entral and {E}ast {A}frica. {G}enotyping of 517 female {M} and {S} mosquitoes revealed nearly complete linkage disequilibrium between the centromeres of the three independently assorting chromosomes. {T}hese results suggest that despite the potential for inter-form gene flow through hybridization, actual (realized) gene flow between {M} and {S} may be substantially less than commonly assumed and may not explain most shared variation. {M}oreover, the possibility of very low gene flow calls into question whether diverged pericentromeric regions-characterized by reduced levels of variation and recombination-are in fact instrumental rather than merely incidental to the speciation process.},
  keywords = {centromeres ; divergent adaptation ; ecological speciation ; malaria vector ; reproductive isolation ; speciation islands},
  booktitle = {},
  journal = {{M}olecular {E}cology},
  volume = {19},
  numero = {5},
  pages = {925--939},
  ISSN = {0962-1083},
  year = {2010},
  DOI = {10.1111/j.1365-294{X}.2010.04531.x},
  URL = {https://www.documentation.ird.fr/hor/fdi:010049274},
}