@article{fdi:010049224,
  title = {{M}ultiple diverse circoviruses infect farm animals and are commonly found in human and chimpanzee feces},
  author = {{L}i, {L}. {L}. and {K}apoor, {A}. and {S}likas, {B}. and {B}amidele, {O}. {S}. and {W}ang, {C}. {L}. and {S}haukat, {S}. and {M}asroor, {M}. {A}. and {W}ilson, {M}. {L}. and {N}django, {J}. {B}. {N}. and {P}eeters, {M}artine and {G}ross-{C}amp, {N}. {D}. and {M}uller, {M}. {N}. and {H}ahn, {B}. {H}. and {W}olfe, {N}. {D}. and {T}riki, {H}. and {B}artkus, {J}. and {Z}aidi, {S}. {Z}. and {D}elwart, {E}.},
  editor = {},
  language = {{ENG}},
  abstract = {{C}ircoviruses are known to infect birds and pigs and can cause a wide range of severe symptoms with significant economic impact. {U}sing viral metagenomics, we identified circovirus-like {DNA} sequences and characterized 15 circular viral {DNA} genomes in stool samples from humans in {P}akistan, {N}igeria, {T}unisia, and the {U}nited {S}tates and from wild chimpanzees. {D}istinct genomic features and phylogenetic analysis indicate that some viral genomes were part of a previously unrecognized genus in the {C}ircoviridae family we tentatively named "{C}yclovirus" whose genetic diversity is comparable to that of all the known species in the {C}ircovirus genus. {C}ircoviridae detection in the stools of {U}. {S}. adults was limited to porcine circoviruses which were also found in most {U}. {S}. pork products. {T}o determine whether the divergent cycloviruses found in non-{U}.{S}. human stools were of dietary origin, we genetically compared them to the cycloviruses in muscle tissue samples of commonly eaten farm animals in {P}akistan and {N}igeria. {L}imited genetic overlap between cycloviruses in human stool samples and local cow, goat, sheep, camel, and chicken meat samples indicated that the majority of the 25 {C}yclovirus species identified might be human viruses. {W}e show that the genetic diversity of small circular {DNA} viral genomes in various mammals, including humans, is significantly larger than previously recognized, and frequent exposure through meat consumption and contact with animal or human feces provides ample opportunities for cyclovirus transmission. {D}etermining the role of cycloviruses, found in 7 to 17% of non-{U}.{S}. human stools and 3 to 55% of non-{U}.{S}. meat samples tested, in both human and animal diseases is now facilitated by knowledge of their genomes.},
  keywords = {},
  booktitle = {},
  journal = {{J}ournal of {V}irology},
  volume = {84},
  numero = {4},
  pages = {1674--1682},
  ISSN = {0022-538{X}},
  year = {2010},
  DOI = {10.1128/jvi.02109-09},
  URL = {https://www.documentation.ird.fr/hor/fdi:010049224},
}