@article{fdi:010049221,
  title = {{A}frican great apes are natural hosts of multiple related malaria species, including {P}lasmodium falciparum},
  author = {{P}rugnolle, {F}ranck and {D}urand, {P}atrick and {N}eel, {C}{\'e}cile and {O}llomo, {B}. and {A}yala, {F}. {J}. and {A}rnathau, {C}{\'e}line and {E}tienne, {L}. and {M}poudi-{N}gole, {E}. and {N}koghe, {D}. and {L}eroy, {E}ric and {D}elaporte, {E}ric and {P}eeters, {M}artine and {R}enaud, {F}ran{\c{c}}ois},
  editor = {},
  language = {{ENG}},
  abstract = {{P}lasmodium reichenowi, a chimpanzee parasite, was until very recently the only known close relative of {P}lasmodium falciparum, the most virulent agent of human malaria. {R}ecently, {P}lasmodium gaboni, another closely related chimpanzee parasite, was discovered, suggesting that the diversity of {P}lasmodium circulating in great apes in {A}frica might have been underestimated. {I}t was also recently shown that {P}. reichenowi is a geographically widespread and genetically diverse chimpanzee parasite and that the world diversity of {P}. falciparum is fully included within the much broader genetic diversity of {P}. reichenowi. {T}he evidence indicates that all extant populations of {P}. falciparum originated from {P}. reichenowi, likely by a single transfer from chimpanzees. {I}n this work, we have studied the diversity of {P}lasmodium species infecting chimpanzees and gorillas in {C}entral {A}frica ({C}ameroon and {G}abon) from both wild-living and captive animals. {T}he studies in wild apes used noninvasive sampling methods. {W}e confirm the presence of {P}. reichenowi and {P}. gaboni in wild chimpanzees. {M}oreover, our results reveal the existence of an unexpected genetic diversity of {P}lasmodium lineages circulating in gorillas. {W}e show that gorillas are naturally infected by two related lineages of parasites that have not been described previously, herein referred to as {P}lasmodium {G}or{A} and {P}. {G}or{B}, but also by {P}. falciparum, a species previously considered as strictly human specific. {T}he continuously increasing contacts between humans and primate populations raise concerns about further reciprocal host transfers of these pathogens.},
  keywords = {cytochrome b gene ; ecology ; evolution ; host specificity ; infectious diseases},
  booktitle = {},
  journal = {{P}roceedings of the {N}ational {A}cademy of {S}ciences of the {U}nited {S}tates of {A}merica},
  volume = {107},
  numero = {4},
  pages = {1458--1463},
  ISSN = {0027-8424},
  year = {2010},
  DOI = {10.1073/pnas.0914440107},
  URL = {https://www.documentation.ird.fr/hor/fdi:010049221},
}