#Phlebotomus perfiliewi transcaucasicus$ is circulating both #Leishmania donovani $and #L. infantum$ in northwest Iran

#Phlebotomus perfiliewi transcaucasicus$ is circulating both #Leishmania donovani $and #L. infantum$ in northwest Iran Oshaghi M.A. auteur aut IRD Ravasan N.M. auteur aut IRD Hide Mallorie auteur aut IRD Javadian E. A. auteur aut IRD Rassi Y. auteur aut IRD Sadraei J. auteur aut IRD Mohebali M. auteur aut IRD Sedaghat M. M. auteur aut IRD Hajjaran H. auteur aut IRD Zarei Z. auteur aut IRD Mohtarami F. auteur aut IRD text journalArticle eng text/pdf born digital access Leishmania infantum is the causative agent of infantile visceral leishmaniasis (IVL) in the Mediterranean Basin and, based on isoenzyme typing of the parasite isolated from dogs; this parasite was considered to predominate in the all foci of IVL in Iran. However, based on PCR detection and sequencing of parasite Cysteine Protease B (CPB), only one out of seven sandfly infections in Phlebotomus perfiliewi transcaucasicus was found to be L. infantum in the current investigation. The six other infections were haplotypes of Leishmania donovani, the causative agent of anthroponotic visceral leishmaniasis (AVL) in West Africa and India. The deduced amino acid of the L. donovani haplotype was found to be novel and the shortest CPB protein reported within the Leishmania spp. Circulation of both L. donovani and L. infantum by P. perfiliewi transcaucasicus, in addition to previous data indicating its ability to circulate L. tropica, suggests that this species, like other vectors of VL, is a permissive vector. Finding L. donovani infecting P. perfiliewi transcaucasicus in the area demands extensive and intensive typing of natural Leishmania infections in epidemiological investigations in Iran and the Mediterranean Basin in general. specialized Leishmania donovani complex Phlebotomus perfiliewi Vector CPB Iran Mediterranean Basin 052 Experimental Parasitology 123 3 218-225 2009 0014-4894 https://www.documentation.ird.fr/hor/fdi:010049195 10.1016/j.exppara.2009.07.004 0014-4894 [F B010049195] https://www.documentation.ird.fr/hor/fdi:010049195 https://www.documentation.ird.fr/intranet/publi/2010/01/010049195.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2010-02-08 2017-08-23 fdi:010049195 fre