@article{fdi:010049092,
  title = {{W}idespread infection with homologues of human parvoviruses {B}19, {PARV}4, and human bocavirus of chimpanzees and gorillas in the wild},
  author = {{S}harp, {C}. {P}. and {L}e{B}reton, {M}. and {K}antola, {K}. and {N}ana, {A}. and {D}iffo, {J}. {L}. and {D}joko, {C}. {F}. and {T}amoufe, {U}. and {K}iyang, {J}. {A}. and {B}abila, {T}. {G}. and {M}poudi-{N}gole, {E}. and {P}ybus, {O}. {G}. and {D}elwart, {E}. and {D}elaporte, {E}ric and {P}eeters, {M}artine and {S}oderlund-{V}enermo, {M}. and {H}edman, {K}. and {W}olfe, {N}. {D}. and {S}immonds, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}nfections with human parvoviruses {B}19 and recently discovered human bocaviruses ({HB}o{V}s) are widespread, while {PARV}4 infections are transmitted parenterally and prevalent specifically in injecting drug users and hemophiliacs. {T}o investigate the exposure and circulation of parvoviruses related to {B}19 virus, {PARV}4, and {HB}o{V} in nonhuman primates, plasma samples collected from 73 {C}ameroonian wild-caught chimpanzees and gorillas and 91 {O}ld {W}orld monkey ({OWM}) species were screened for antibodies to recombinant {B}19 virus, {PARV}4, and {HB}o{V} {VP}2 antigens by enzyme-linked immunosorbent assay ({ELISA}). {M}oderate to high frequencies of seroreactivity to {PARV}4 (63% and 18% in chimpanzees and gorillas, respectively), {HB}o{V} (73% and 36%), and {B}19 virus (8% and 27%) were recorded for apes, while {OWM}s were uniformly negative (for {PARV}4 and {B}19 virus) or infrequently reactive (3% for {HB}o{V}). {F}or genetic characterization, plasma samples and 54 fecal samples from chimpanzees and gorillas collected from {C}ameroonian forest floors were screened by {PCR} with primers conserved within {E}rythrovirus, {B}ocavirus, and {PARV}4 genera. {T}wo plasma samples (chimpanzee and baboon) were positive for {PARV}4, while four fecal samples were positive for {HB}o{V}-like viruses. {T}he chimpanzee {PARV}4 variant showed 18% and 15% nucleotide sequence divergence in {NS} and {VP}1/2, respectively, from human variants (9% and 7% amino acid, respectively), while the baboon variant was substantially more divergent, mirroring host phylogeny. {A}pe {HB}o{V} variants showed complex sequence relationships with human viruses, comprising separate divergent homologues of {HB}o{V}1 and the recombinant {HB}o{V}3 species in chimpanzees and a novel recombinant species in gorillas. {T}his study provides the first evidence for widespread circulation of parvoviruses in primates and enables future investigations of their epidemiology, host specificity, and (co)evolutionary histories.},
  keywords = {},
  booktitle = {},
  journal = {{J}ournal of {V}irology},
  volume = {84},
  numero = {19},
  pages = {10289--10296},
  ISSN = {0022-538{X}},
  year = {2010},
  DOI = {10.1128/jvi.01304-10},
  URL = {https://www.documentation.ird.fr/hor/fdi:010049092},
}