%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Poinsignon, Anne
%A Samb, B.
%A Doucoure, Souleymane
%A Dramé, Papa Maktar
%A Sarr, J.B.
%A Sow, Cheikh
%A Cornélie, Sylvie
%A Maiga, S.
%A Thiam, C.
%A Rogerie, F.
%A Guindo, S.
%A Hermann, E.
%A Simondon, Francois
%A Dia, I.
%A Riveau, G.
%A Konate, L.
%A Remoué, Franck
%T First attempt to validate the gSG6-P1 salivary peptide as an immuno-epidemiological tool for evaluating human exposure to Anopheles funestus bites
%D 2010
%L fdi:010049086
%G ENG
%J Tropical Medicine and International Health
%@ 1360-2276
%K Anopheles ; salivary protein ; environmental exposure ; biological marker ; Senegal
%K SENEGAL
%M ISI:000281798400013
%N 10
%P 1198-1203
%R 10.1111/j.1365-3156.2010.02611.x
%U https://www.documentation.ird.fr/hor/fdi:010049086
%> https://www.documentation.ird.fr/intranet/publi/2010/10/010049086.pdf
%V 15
%W Horizon (IRD)
%X OBJECTIVE The development of a biomarker of exposure based on the evaluation of the human antibody response specific to Anopheles salivary proteins seems promising in improving malaria control. The IgG response specific to the gSG6-P1 peptide has already been validated as a biomarker of An. gambiae exposure. This study represents a first attempt to validate the gSG6-P1 peptide as an epidemiological tool evaluating exposure to An. funestus bites, the second main malaria vector in subSaharan Africa. METHODS A multi-disciplinary survey was performed in a Senegalese village where An. funestus represents the principal anopheline species. The IgG antibody level specific to gSG6-P1 was evaluated and compared in the same children before, at the peak and after the rainy season. RESULTS Two-thirds of the children developed a specific IgG response to gSG6-P1 during the study period and - more interestingly - before the rainy season, when An. funestus was the only anopheline species reported. The specific IgG response increased during the An. funestus exposure season, and a positive association between the IgG level and the level of exposure to An. funestus bites was observed. CONCLUSIONS The results suggest that the evaluation of the IgG response specific to gSG6-P1 in children could also represent a biomarker of exposure to An. funestus bites. The availability of such a biomarker evaluating the exposure to both main Plasmodium falciparum vectors in Africa could be particularly relevant as a direct criterion for the evaluation of the efficacy of vector control strategies.
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