@article{fdi:010049086,
  title = {{F}irst attempt to validate the g{SG}6-{P}1 salivary peptide as an immuno-epidemiological tool for evaluating human exposure to {A}nopheles funestus bites},
  author = {{P}oinsignon, {A}nne and {S}amb, {B}. and {D}oucoure, {S}ouleymane and {D}ram{\'e}, {P}apa {M}aktar and {S}arr, {J}.{B}. and {S}ow, {C}heikh and {C}orn{\'e}lie, {S}ylvie and {M}aiga, {S}. and {T}hiam, {C}. and {R}ogerie, {F}. and {G}uindo, {S}. and {H}ermann, {E}. and {S}imondon, {F}rancois and {D}ia, {I}. and {R}iveau, {G}. and {K}onate, {L}. and {R}emou{\'e}, {F}ranck},
  editor = {},
  language = {{ENG}},
  abstract = {{OBJECTIVE} {T}he development of a biomarker of exposure based on the evaluation of the human antibody response specific to {A}nopheles salivary proteins seems promising in improving malaria control. {T}he {I}g{G} response specific to the g{SG}6-{P}1 peptide has already been validated as a biomarker of {A}n. gambiae exposure. {T}his study represents a first attempt to validate the g{SG}6-{P}1 peptide as an epidemiological tool evaluating exposure to {A}n. funestus bites, the second main malaria vector in sub{S}aharan {A}frica. {METHODS} {A} multi-disciplinary survey was performed in a {S}enegalese village where {A}n. funestus represents the principal anopheline species. {T}he {I}g{G} antibody level specific to g{SG}6-{P}1 was evaluated and compared in the same children before, at the peak and after the rainy season. {RESULTS} {T}wo-thirds of the children developed a specific {I}g{G} response to g{SG}6-{P}1 during the study period and - more interestingly - before the rainy season, when {A}n. funestus was the only anopheline species reported. {T}he specific {I}g{G} response increased during the {A}n. funestus exposure season, and a positive association between the {I}g{G} level and the level of exposure to {A}n. funestus bites was observed. {CONCLUSIONS} {T}he results suggest that the evaluation of the {I}g{G} response specific to g{SG}6-{P}1 in children could also represent a biomarker of exposure to {A}n. funestus bites. {T}he availability of such a biomarker evaluating the exposure to both main {P}lasmodium falciparum vectors in {A}frica could be particularly relevant as a direct criterion for the evaluation of the efficacy of vector control strategies.},
  keywords = {{A}nopheles ; salivary protein ; environmental exposure ; biological marker ; {S}enegal ; {SENEGAL}},
  booktitle = {},
  journal = {{T}ropical {M}edicine and {I}nternational {H}ealth},
  volume = {15},
  numero = {10},
  pages = {1198--1203},
  ISSN = {1360-2276},
  year = {2010},
  DOI = {10.1111/j.1365-3156.2010.02611.x},
  URL = {https://www.documentation.ird.fr/hor/fdi:010049086},
}