%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Diallo, T. O.
%A Remoué, Franck
%A Gaayeb, L.
%A Schacht, A. M.
%A Charrier, N.
%A De Clerck, D.
%A Dompnier, J. P.
%A Pillet, S.
%A Garraud, O.
%A N'Diaye, A. A.
%A Riveau, G.
%T Schistosomiasis coinfection in children influences acquired immune response against Plasmodium falciparum malaria antigens
%D 2010
%L fdi:010049075
%G ENG
%J Plos One
%@ 1932-6203
%M ISI:000281815800026
%N 9
%P e12764
%R 10.1371/journal.pone.0012764
%U https://www.documentation.ird.fr/hor/fdi:010049075
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-08/010049075.pdf
%V 5
%W Horizon (IRD)
%X Background: Malaria and schistosomiasis coinfection frequently occurs in tropical countries. This study evaluates the influence of Schistosoma haematobium infection on specific antibody responses and cytokine production to recombinant merozoite surface protein-1-19 (MSP1-(19)) and schizont extract of Plasmodium falciparum in malaria-infected children. Methodology: Specific IgG1 to MSP1-(19), as well as IgG1 and IgG3 to schizont extract were significantly increased in coinfected children compared to P. falciparum mono-infected children. Stimulation with MSP1-(19) lead to a specific production of both interleukin-10 (IL-10) and interferon-gamma (IFN-gamma), whereas the stimulation with schizont extract produced an IL-10 response only in the coinfected group. Conclusions: Our study suggests that schistosomiasis coinfection favours anti-malarial protective antibody responses, which could be associated with the regulation of IL-10 and IFN-gamma production and seems to be antigen-dependent. This study demonstrates the importance of infectious status of the population in the evaluation of acquired immunity against malaria and highlights the consequences of a multiple infection environment during clinical trials of anti-malaria vaccine candidates.
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