@article{fdi:010049075,
  title = {{S}chistosomiasis coinfection in children influences acquired immune response against {P}lasmodium falciparum malaria antigens},
  author = {{D}iallo, {T}. {O}. and {R}emou{\'e}, {F}ranck and {G}aayeb, {L}. and {S}chacht, {A}. {M}. and {C}harrier, {N}. and {D}e {C}lerck, {D}. and {D}ompnier, {J}. {P}. and {P}illet, {S}. and {G}arraud, {O}. and {N}'{D}iaye, {A}. {A}. and {R}iveau, {G}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {M}alaria and schistosomiasis coinfection frequently occurs in tropical countries. {T}his study evaluates the influence of {S}chistosoma haematobium infection on specific antibody responses and cytokine production to recombinant merozoite surface protein-1-19 ({MSP}1-(19)) and schizont extract of {P}lasmodium falciparum in malaria-infected children. {M}ethodology: {S}pecific {I}g{G}1 to {MSP}1-(19), as well as {I}g{G}1 and {I}g{G}3 to schizont extract were significantly increased in coinfected children compared to {P}. falciparum mono-infected children. {S}timulation with {MSP}1-(19) lead to a specific production of both interleukin-10 ({IL}-10) and interferon-gamma ({IFN}-gamma), whereas the stimulation with schizont extract produced an {IL}-10 response only in the coinfected group. {C}onclusions: {O}ur study suggests that schistosomiasis coinfection favours anti-malarial protective antibody responses, which could be associated with the regulation of {IL}-10 and {IFN}-gamma production and seems to be antigen-dependent. {T}his study demonstrates the importance of infectious status of the population in the evaluation of acquired immunity against malaria and highlights the consequences of a multiple infection environment during clinical trials of anti-malaria vaccine candidates.},
  keywords = {},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {5},
  numero = {9},
  pages = {e12764},
  ISSN = {1932-6203},
  year = {2010},
  DOI = {10.1371/journal.pone.0012764},
  URL = {https://www.documentation.ird.fr/hor/fdi:010049075},
}