@article{fdi:010048955,
  title = {{C}hromosomal plasticity and evolutionary potential in the malaria vector {A}nopheles gambiae sensu stricto : insights from three decades of rare paracentric inversions},
  author = {{P}ombi, {M}. and {C}aputo, {B}. and {S}imard, {F}rederic and {A} {D}i {D}eco, {M}. and {C}oluzzi, {M}. and {D}ella {T}orre, {A}. and {C}onstantini, {C}arlo and {B}esansky, {N}.{J}. and {P}etrarca, {V}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground. {I}n the {A}nopheles gambiae complex, paracentric chromosomal inversions are non-randomly distributed along the complement: 18/31 (58%) of common polymorphic inversions are on chromosome arm 2{R}, which represents only ~30% of the complement. {M}oreover, in {A}n. gambiae sensu stricto, 6/7 common polymorphic inversions occur on 2{R}. {M}ost of these inversions are considered markers of ecological adaptation that increase the fitness of the carriers of alternative karyotypes in contrasting habitats. {H}owever, little is known about the evolutionary forces responsible for their origin and subsequent establishment in field populations.{R}esults. {H}ere, we present data on 82 previously undescribed rare chromosomal inversions ({RCI}s) recorded during extensive field sampling in 16 {A}frican countries over a 30 year period, which may shed light on the dynamics of chromosomal plasticity in {A}n. gambiae. {W}e analyzed breakpoint distribution, length, and geographic distribution of {RCI}s, and compared these measures to those of the common inversions. {W}e found that {RCI}s, like common inversions, are disproportionately clustered on 2{R}, which may indicate that this arm is especially prone to breakages. {H}owever, contrasting patterns were observed between the geographic distribution of common inversions and {RCI}s. {RCI}s were equally frequent across biomes and on both sides of the {G}reat {R}ift {V}alley ({GRV}), whereas common inversions predominated in arid ecological settings and west of the {GRV}. {M}oreover, the distribution of {RCI} lengths followed a random pattern while common inversions were significantly less frequent at shorter lengths.{C}onclusion. {B}ecause 17/82 (21%) {RCI}s were found repeatedly at very low frequencies - at the same sampling location in different years and/or in different sampling locations - we suggest that {RCI}s are subject mainly to drift under unperturbed ecological conditions. {N}evertheless, {RCI}s may represent an important reservoir of genetic variation for {A}n. gambiae in response to environmental changes, further testifying to the considerable evolutionary potential hidden within this pan-{A}frican malaria vector.},
  keywords = {{PALUDISME} ; {VECTEUR} ; {VARIABILITE} {GENETIQUE} ; {CARYOTYPE} ; {REPARTITION} {GEOGRAPHIQUE} ; {ENVIRONNEMENT} ; {ANALYSE} {DIACHRONIQUE} ; {ANALYSE} {GENETIQUE} ; {AFRIQUE} {SUBSAHARIENNE}},
  booktitle = {},
  journal = {{BMC} {E}volutionary {B}iology},
  volume = {8},
  numero = {309},
  pages = {1--10},
  ISSN = {1471-2148},
  year = {2008},
  DOI = {10.1186/1471-2148-8-309},
  URL = {https://www.documentation.ird.fr/hor/fdi:010048955},
}