@article{fdi:010048690,
  title = {{P}erinatal zidovudine prophylaxis in {HIV} type-1-infected pregnant women with thalassaemia carriage in {T}hailand},
  author = {{B}riand, {N}. and {P}ornprasert, {S}. and {N}go-{G}iang-{H}uong, {N}icole and {G}alacteros, {F}. and {P}issard, {S}. and {T}atu, {T}. and {S}anguansermsri, {T}. and {J}ourdain, {G}onzague and {L}allemant, {M}arc and {L}e {C}oeur, {S}ophie},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {T}o investigate a possible interaction between alpha-thalassaemia, beta-thalassaemia and haemoglobin-{E} trait and the haematological parameters of {HIV} type-1 ({HIV}-1)-infected pregnant women receiving zidovudine prophylaxis for the prevention of mother-to-child {HIV}-1 transmission in {T}hailand. {M}ethods: {T}he study sample was composed of {HIV}-1-infected pregnant women receiving zidovudine (300 mg twice daily) from 28 weeks of gestational age to delivery as part of the {P}erinatal {HIV} {P}revention {T}rial ({PHPT}-1), a large trial investigating zidovudine use in pregnancy. {T}hese women were randomly selected and screened for haemoglobin abnormalities. {H}aemoglobin levels, haematocrit and erythrocyte, leukocyte, absolute neutrophil and absolute lymphocyte counts were measured at 26, 32 and 35 weeks of gestation and at delivery. {PCR} genotyping techniques were used to screen for haemoglobin abnormalities, which included alpha-thalassaemia-1 {S}outheast {A}sian type deletion, beta-thalassaernia mutation (codons 41/42 [-{TCTT}], codon 17 [{A} -> {T}], intervening sequence-1 nucleotide 1 [{G} -> {T}], codons 71/72 [+{A}]) and haemoglobin-{E} trait. {T}he evolution of haematological parameters between 26 weeks and delivery was compared according to thalassaemia carriage using linear mixed models adjusted for baseline sociodemographic characteristics, {HIV} clinical stage, {CD}4(+) {T}-cell count and viral load. {R}esults: {A}t baseline, women with thalassaemia or haemoglobin-{E} trait had significantly lower haemoglobin level and red blood cell counts than women with no haemoglobin abnormalities, whereas absolute neutrophil and leukocyte counts were significantly higher. {E}xposure to zidovudine until delivery did not increase this difference. {C}onclusions: {Z}idovudine exposure did not appear to have increased haematological toxicity in {HIV}-1-infected pregnant women with thalassaemia.},
  keywords = {},
  booktitle = {},
  journal = {{A}ntiviral {T}herapy},
  volume = {14},
  numero = {1},
  pages = {117--122},
  ISSN = {1359-6535},
  year = {2009},
  URL = {https://www.documentation.ird.fr/hor/fdi:010048690},
}