Pennetier Cédric auteur aut IRD Costantini Carlo auteur aut IRD Corbel Vincent auteur aut IRD Licciardi Sèverine auteur aut IRD Dabiré R. K. auteur aut IRD Lapied B. auteur aut IRD Chandre Fabrice auteur aut IRD Hougard Jean-Marc auteur aut IRD text journalArticle eng text/pdf reformatted digital access Background: Chemicals are used on bed nets in order to prevent infected bites and to kill aggressive malaria vectors. Because pyrethroid resistance has become widespread in the main malaria vectors, research for alternative active ingredients becomes urgent. Mixing a repellent and a non-pyrethroid insecticide seemed to be a promising tool as mixtures in the laboratory showed the same features as pyrethroids. Methodology/Principal Findings: We present here the results of two trials run against free-flying Anopheles gambiae populations comparing the effects of two insect repellents (either DEET or KBR 3023, also known as icaridin) and an organophosphate insecticide at low-doses (pirimiphos-methyl, PM) used alone and in combination on bed nets. We showed that mixtures of PM and the repellents induced higher exophily, blood feeding inhibition and mortality among wild susceptible and resistant malaria vectors than compounds used alone. Nevertheless the synergistic interactions are only involved in the high mortality induced by the two mixtures. Conclusion: These field trials argue in favour of the strategy of mixing repellent and organophosphate on bed nets to better control resistant malaria vectors. specialized 052 4 11 e7896 [8 ] 2009 1932-6203 https://www.documentation.ird.fr/hor/fdi:010048503 10.1371/journal.pone.0007896 1932-6203 [F B010048503] https://www.documentation.ird.fr/hor/fdi:010048503 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-08/010048503.pdf IRD - Base Horizon / Pleins textes 2010-02-08 2021-06-08 fdi:010048503 fre