Low prevalence of HIV Type 1 drug resistance mutations in untreated, recently infected patients from Burkina Faso, Cote d'Ivoire, Senegal, Thailand, and Vietnam : the ANRS 12134 study

Low prevalence of HIV Type 1 drug resistance mutations in untreated, recently infected patients from Burkina Faso, Cote d'Ivoire, Senegal, Thailand, and Vietnam : the ANRS 12134 study Ayouba Ahidjo auteur aut IRD Lien T.T.X. auteur aut IRD Nouhin J. auteur aut IRD Vergne Laurence auteur aut IRD Aghokeng Fobang Avelin auteur aut IRD Ngo-Giang-Huong Nicole auteur aut IRD Diop H. auteur aut IRD Touré Kane C. auteur aut IRD Valéa D. auteur aut IRD Rouet F. auteur aut IRD Joulia-Ekaza D. auteur aut IRD Toni T. d'A. auteur aut IRD Nerrienet E. auteur aut IRD Mpoudi Ngole E. auteur aut IRD Delaporte Eric auteur aut IRD Costagliola D. auteur aut IRD Peeters Martine auteur aut IRD Chaix M.L. auteur aut IRD text journalArticle eng text/pdf born digital access The frequency of transmitted HIV drug resistance (HIVDR) was evaluated in the context of rapid scale-up of antiretroviral treatment in Thailand, Vietnam, Burkina Faso, Cote d'Ivoire, and Senegal by using an adaptation of the WHO generic protocol of the HIV Drug Resistance Threshold Survey (HIVDR-TS) for sample collection and classification. Resistance-associated mutations were interpreted using the 2009 WHO list for epidemiological surveys. We included 266 subjects from the five study sites. Of the 266 RT and PR sequences analyzed, two from Vietnam harbored virus with major drug resistance mutations (G190A in RT for one individual and M46I in PR for the second individual). Phylogenetic analysis revealed that CRF01_AE predominates (>90%) in Thailand and Vietnam. CRF02 (>65%) cocirculates with other HIV-1 variants in Senegal and Cote d'Ivoire. The prevalence of HIVDRM is scored as low (<= 5%) in all the five sites for the three drug classes analyzed. A continuous population survey for HIVDRM will provide a rational basis for maintaining or changing the current first line regimen in these countries. specialized BURKINA FASO COTE D'IVOIRE SENEGAL THAILANDE VIET NAM 052 Aids Research and Human Retroviruses 25 11 1193-1196 2009 0889-2229 https://www.documentation.ird.fr/hor/fdi:010048464 10.1089/aid.2009.0142 0889-2229 [F B010048464] https://www.documentation.ird.fr/hor/fdi:010048464 https://www.documentation.ird.fr/intranet/publi/2010/01/010048464.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2010-02-08 2017-08-23 fdi:010048464 fre