@article{fdi:010048462,
  title = {{A}ntibody drop in newborns congenitally infected by {T}rypanosoma cruzi treated with benznidazole},
  author = {{C}hippaux, {J}ean-{P}hilippe and {S}alas {C}lavijo, {A}lejandra and {S}antalla, {J}. {A}. and {P}ostigo, {J}orge and {S}chneider, {D}ominique and {B}rutus, {L}aurent},
  editor = {},
  language = {{ENG}},
  abstract = {{OBJECTIVE} {T}o compare the drop of {C}hagas antibody titres between non-infected and congenitally infected newborns treated by two doses of benznidazole, aiming at evaluating the recovery time and giving recommendations regarding serological criteria of recovery. {METHODS} {D}uring a clinical trial, the drop of {T}rypanosoma cruzi antibody titres measured by {ELISA} tests was followed during the first year of life in congenitally infected newborns treated with different doses of benznidazole and compared to {T}. cruzi antibody titres in non-parasitaemic newborns. {C}onfirmation of recovery was given by two negative serological tests: {C}hagas {S}tat-{P}ak ({R}) ({CSP}) (immunochromatography) and {C}hagatest ({R}) v3.0 ({ELISA}). {RESULTS} {I}n non-parasitaemic infants of infected mothers, antibodies of maternal origin disappeared in <8 months while in infected infants, {T}. cruzi antibodies decreased more slowly and disappeared in 9-16 months allowing to confirm the recovery. {A}ll {CSP} tests were negative before the ninth month while about 10% of {ELISA} tests remained positive at the 12th month. {CONCLUSIONS} {R}ecovery may be confirmed in most cases at 10 months. {T}he {CSP} test was compared to {C}hagatest ({R}) v3.0 {ELISA} and appeared to give a reliable response. {T}he decrease rate of antibodies does not depend on treatment modes.},
  keywords = {{C}hagas disease ; congenital infection ; treatment ; benznidazole ; immune response},
  booktitle = {},
  journal = {{T}ropical {M}edicine and {I}nternational {H}ealth},
  volume = {15},
  numero = {1},
  pages = {87--93},
  ISSN = {1360-2276},
  year = {2010},
  DOI = {10.1111/j.1365-3156.2009.02431.x},
  URL = {https://www.documentation.ird.fr/hor/fdi:010048462},
}