@article{fdi:010048438,
  title = {{G}enetic characterization of the complete genome of a highly divergent simian {T}-lymphotropic virus ({STLV}) type 3 from a wild {C}ercopithecus mona monkey},
  author = {{S}intasath, {D}. {M}. and {W}olfe, {N}. {D}. and {Z}heng, {H}. {Q}. and {L}e{B}reton, {M}. and {P}eeters, {M}artine and {T}amoufe, {U}. and {D}joko, {C}. {F}. and {D}iffo, {J}. {L}. {D}. and {M}poudi-{N}gole, {E}. and {H}eneine, {W}. and {S}witzer, {W}. {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {T}he recent discoveries of novel human {T}-lymphotropic virus type 3 ({HTLV}-3) and highly divergent simian {T}-lymphotropic virus type 3 ({STLV}-3) subtype {D} viruses from two different monkey species in southern {C}ameroon suggest that the diversity and cross-species transmission of these retroviruses are much greater than currently appreciated. {R}esults: {W}e describe here the first full-length sequence of a highly divergent {STLV}-3d({C}mo8699{AB}) virus obtained by {PCR}-based genome walking using {DNA} from two dried blood spots ({DBS}) collected from a wild-caught {C}ercopithecus mona monkey. {T}he genome of {STLV}-3d({C}mo8699{AB}) is 8913-bp long and shares only 77% identity to other {PTLV}-3s. {P}hylogenetic analyses using {B}ayesian and maximum likelihood inference clearly show that this highly divergent virus forms an independent lineage with high posterior probability and bootstrap support within the diversity of {PTLV}-3. {M}olecular dating of concatenated gag-pol-envtax sequences inferred a divergence date of about 115,117 years ago for {STLV}-3d({C}mo8699{AB}) indicating an ancient origin for this newly identified lineage. {M}ajor structural, enzymatic, and regulatory gene regions of {STLV}-3d({C}mo8699{AB}) are intact and suggest viral replication and a predicted pathogenic potential comparable to other {PTLV}-3s. {C}onclusion: {W}hen taken together, the inferred ancient origin of {STLV}-3d({C}mo8699{AB}), the presence of this highly divergent virus in two primate species from the same geographical region, and the ease with which {STLV}s can be transmitted across species boundaries all suggest that {STLV}-3d may be more prevalent and widespread. {G}iven the high human exposure to nonhuman primates in this region and the unknown pathogenicity of this divergent {PTLV}-3, increased surveillance and expanded prevention activities are necessary. {O}ur ability to obtain the complete viral genome from {DBS} also highlights further the utility of this method for molecular-based epidemiologic studies.},
  keywords = {},
  booktitle = {},
  journal = {{R}etrovirology},
  volume = {6},
  numero = {},
  pages = {97},
  ISSN = {1742-4690},
  year = {2009},
  DOI = {10.1186/1742-4690-6-97},
  URL = {https://www.documentation.ird.fr/hor/fdi:010048438},
}