@article{fdi:010048436,
  title = {{P}lasmodium falciparum exposure in utero, maternal age and parity influence the innate activation of foetal antigen presenting cells},
  author = {{F}ievet, {N}adine and {V}arani, {S}. and {I}bitokou, {S}amad and {B}riand, {V}al{\'e}rie and {L}ouis, {S}. and {P}errin, {R}. {X}. and {M}assougbogji, {A}. and {H}osmalin, {A}. and {T}roye-{B}lomberg, {M}. and {D}eloron, {P}hilippe},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {M}alaria in pregnancy is associated with immunological abnormalities in the newborns, such as hampered {T}-helper 1 responses and increased {T}-regulatory responses, while the effect of maternal {P}lasmodium falciparum infection on foetal innate immunity is still controversial. {M}aterials and methods: {T}he immunophenotype and cytokine release by dendritic cells ({DC}) and monocytes were evaluated in cord blood from 59 {B}eninese women with or without malaria infection by using flow cytometry. {R}esults: {A}ccumulation of malaria pigment in placenta was associated with a partial maturation of cord blood myeloid and plasmacytoid {DC}, as reflected by an up-regulated expression of the major histocompatibility complex class {II} molecules, but not {CD}86 molecules. {C}ells of newborns of mothers with malaria pigment in their placenta also exhibited significantly increased cytokine responses upon {TLR}9 stimulation. {I}n addition, maternal age and parity influenced the absolute numbers and activation status of cord blood antigen-presenting cells. {L}astly, maternal age, but not parity, influenced {TLR}3, 4 and 9 responses in cord blood cells. {D}iscussion: {O}ur findings support the view that placental parasitization, as indicated by the presence of malaria pigment in placental leukocytes, is significantly associated with partial maturation of different {DC} subsets and also to slightly increased responses to {TLR}9 ligand in cord blood. {A}dditionally, other factors, such as maternal age and parity should be taken into consideration when analysing foetal/neonatal innate immune responses. {C}onclusion: {T}hese data advocate a possible mechanism by which {PAM} may modulate foetal/neonatal innate immunity.},
  keywords = {},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {8},
  numero = {},
  pages = {251},
  ISSN = {1475-2875},
  year = {2009},
  DOI = {10.1186/1475-2875-8-251},
  URL = {https://www.documentation.ird.fr/hor/fdi:010048436},
}