@article{fdi:010048433,
  title = {{S}elf-reported data : a major tool to assess compliance with anti-malarial combination therapy among children in {S}enegal},
  author = {{S}ouares, {A}ur{\'e}lia and {M}oulin {E}smard, {P}atricia and {S}arrassat, {S}ophie and {C}arlotti, {M}. {P}. and {L}alou, {R}ichard and {L}e {H}esran, {J}ean-{Y}ves},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {A}lthough there are many methods available for measuring compliance, there is no formal gold standard. {D}ifferent techniques used to measure compliance were compared among children treated by the anti-malarial amodiaquine/sulphadoxine-pyrimethamine ({AQ}/{SP}) combination therapy, in use in {S}enegal between 2004 and 2006. {M}ethods: {T}he study was carried out in 2004, in five health centres located in the {T}hies region ({S}enegal). {C}hildren who had {AQ}/{SP} prescribed for three and one day respectively at the health centre were recruited. {T}he day following the theoretical last intake of {AQ}, venous blood, and urine samples were collected for anti-malarial drugs dosage. {C}aregivers and children above five years were interviewed concerning children's drug intake. {R}esults: {A}mong the children, 64.7% adhered to 80% of the prescribed dose and only 37.7% were strict full adherent to the prescription. {T}here was 72.7% agreement between self-reported data and blood drug dosage for amodiaquine treatment. {C}oncerning {SP}, results found that blood dosages were 91.4% concordant with urine tests and 90% with self-reported data based on questionnaires. {C}onclusion: {S}elf-reported data could provide useful quantitative information on drug intake and administration. {U}nder strict methodological conditions this method, easy to implement, can be used to describe patients' behaviors and their use of new anti-malarial treatment. {S}elf-reported data is a major tool for assessing compliance in resource poor countries. {B}lood and urine drug dosages provide qualitative results that confirm any drug intake. {U}rine assays for {SP} could be useful to obtain public health data, for example on chemoprophylaxis among pregnant women.},
  keywords = {{SENEGAL}},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {8},
  numero = {},
  pages = {257},
  ISSN = {1475-2875},
  year = {2009},
  DOI = {10.1186/1475-2875-8-257},
  URL = {https://www.documentation.ird.fr/hor/fdi:010048433},
}