@article{fdi:010048403,
  title = {{Q}uassinoid constituents of {Q}uassia amara {L}. leaf herbal tea. {I}mpact on its antimalarial activity and cytotoxicity},
  author = {{H}ouel, {E}. and {B}ertani, {S}. and {B}ourdy, {G}enevi{\`e}ve and {D}eharo, {E}ric and {J}ullian, {V}al{\'e}rie and {V}alentin, {A}. and {C}hevalley, {S}{\'e}verine and {S}tien, {D}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}im of the study: {O}ur objective was to assess whether it could be contemplated to recommend {Q}uassia amara young leaf tea for treatment against malaria. and if yes. set up a standard protocol for preparing the herbal tea. {M}aterials and methods: {T}he leaf tea was extracted with methylene chloride and the organic extract was fractionated with {HPLC}. {P}ure compounds were characterized and their in vitro cytotoxicity and antiplasmodial activity was determined. {R}esults and discussion: {W}e discovered that antimalarial {Q}uassia amara young leaf tea contains several quassinoids: simalikalactone {D} ({S}k{D}. 1), picrasin {B} (2). picrasin {H} (3), neoquassin (4), quassin (5), picrasin 1(6) and picrasin {J} (7). {T}hese last two compounds are new. {I}n addition. our experiments demonstrate that both biological activity and cytotoxicity of the remedy may be attributed solely to the presence of {S}k{D}. {C}onclusion: {I}n conclusion, this preparation {S}hould not be recommended for treatment of malaria until a clinical {S}tudy in humans is performed with {S}k{D}.},
  keywords = {{Q}uassia amara {L}. ; {S}imaroubaceae ; {L}eaf tea ; {A}ntimalarial activity ; {C}ytotoxicity ; {S}imalikalactone {D}},
  booktitle = {},
  journal = {{J}ournal of {E}thnopharmacology},
  volume = {126},
  numero = {1},
  pages = {114--118},
  ISSN = {0378-8741},
  year = {2009},
  DOI = {10.1016/j.jep.2009.07.037},
  URL = {https://www.documentation.ird.fr/hor/fdi:010048403},
}