@article{fdi:010048386,
  title = {{R}educing costs and operational constraints of dengue vector control by targeting productive breeding places : a multi-country non-inferiority cluster randomized trial},
  author = {{T}un-{L}in, {W}. and {L}enhart, {A}. and {N}am, {V}. {S}. and {R}ebollar-{T}ellez, {E}. and {M}orrison, {A}. {C}. and {B}arbazan, {P}hilippe and {C}ote, {M}. and {M}idega, {J}. and {S}anchez, {F}. and {M}anrique-{S}aide, {P}. and {K}roeger, {A}. and {N}athan, {M}. {B}. and {M}eheus, {F}. and {P}etzold, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{OBJECTIVES} {T}o test the non-inferiority hypothesis that a vector control approach targeting only the most productive water container types gives the same or greater reduction of the vector population as a non-targeted approach in different ecological settings and to analyse whether the targeted intervention is less costly. {METHODS} {C}luster randomized trial in eight study sites ({V}enezuela, {M}exico, {P}eru, {K}enya, {T}hailand, {M}yanmar, {V}ietnam, {P}hilippines), with each study area divided into 18-20 clusters (sectors or neighbourhoods) of approximately 50-100 households each. {U}sing a baseline pupal-demographic survey, the most productive container types were identified which produced >= 55% of all {A}e. aegypti pupae. {C}lusters were then paired based on similar pupae per person indices. {O}ne cluster from each pair was randomly allocated to receive the targeted vector control intervention; the other received the 'blanket' (non-targeted) intervention attempting to reach all water holding containers. {RESULTS} {T}he pupal-demographic baseline survey showed a large variation of productive container types across all study sites. {I}n four sites the vector control interventions in both study arms were insecticidal and in the other four sites, non-insecticidal (environmental management and/or biological control methods). {B}oth approaches were associated with a reduction of outcome indicators in the targeted and non-targeted intervention arm of the six study sites where the follow up study was conducted ({PPI}, {P}upae per {P}erson {I}ndex and {BI}, {B}reteau {I}ndex). {T}argeted interventions were as effective as non-targeted ones in terms of {PPI}. {T}he direct costs per house reached were lower in targeted intervention clusters than in non-targeted intervention clusters with only one exception, where the targeted intervention was delivered through staff-intensive social mobilization. {CONCLUSIONS} {T}argeting only the most productive water container types ( roughly half of all water holding container types) was as effective in lowering entomological indices as targeting all water holding containers at lower implementation costs. {F}urther research is required to establish the most efficacious method or combination of methods for targeted dengue vector interventions.},
  keywords = {dengue ; vector control ; targeted intervention ; efficiency of interventions},
  booktitle = {},
  journal = {{T}ropical {M}edicine and {I}nternational {H}ealth},
  volume = {14},
  numero = {9},
  pages = {1143--1153},
  ISSN = {1360-2276},
  year = {2009},
  DOI = {10.1111/j.1365-3156.2009.02341.x},
  URL = {https://www.documentation.ird.fr/hor/fdi:010048386},
}