Cournil Amandine auteur aut IRD Coly A.N. auteur aut IRD Diallo Aldiouma auteur aut IRD Bork Simondon Kirsten auteur aut IRD text journalArticle eng text/pdf reformatted digital access Background Evidence suggests that intrauterine growth restriction followed by rapid post-natal growth is associated with high blood pressure. We assessed the effect of early size and post-natal growth on blood pressure in a population from West Africa, where fetal growth retardation and childhood malnutrition are common. Methods A total of 1288 Senegalese subjects were followed from infancy to young adulthood (mean age 17.9 years). Adult systolic blood pressure (SBP) was regressed on infant and adult anthropometric characteristics. Results In unadjusted analyses, infant size was positively associated with adult SBP (1.1 +/- 03; P = 0.001 for weight; 0.7 +/- 0.3; P = 0.04 for length). With adjustment for current size, the regression coefficients for infant size were reversed (-0.2 +/- 0.3; P = 0.51 for weight; -0.3 +/- 0.3; P = 0.35 for length). SBP increased by 4.1 and 2.9 mmHg for 1 standard deviation (SD) increase in current weight or height, respectively. No interaction between infant size and current size was found in the overall models (P = 0.11 for weight, P = 0.95 for height), but this term interacted with sex for weight effect. A negative interaction was found in males (-0.9 +/- 0.4; P = 0.02) but not in females (0.3 +/- 0.4; P = 0.46). The association of current weight with SBP was stronger in lighter weight male infants. Conclusions These findings support the hypothesis that subjects who were small in early life and experienced enhanced post-natal growth have higher levels of SBP, even in low-income settings. specialized Blood pressure infant body size growth developing countries cohort study 050 38 5 1401-1410 2009 0300-5771 https://www.documentation.ird.fr/hor/fdi:010048330 10.1093/ije/dyp255 0300-5771 [F B010048330] https://www.documentation.ird.fr/hor/fdi:010048330 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers14-06/010048330.pdf IRD - Base Horizon / Pleins textes 2009-12-03 2017-08-23 fdi:010048330 fre