@article{fdi:010048330, title = {{E}nhanced post-natal growth is associated with elevated blood pressure in young {S}enegalese adults}, author = {{C}ournil, {A}mandine and {C}oly, {A}.{N}. and {D}iallo, {A}ldiouma and {B}ork {S}imondon, {K}irsten}, editor = {}, language = {{ENG}}, abstract = {{B}ackground {E}vidence suggests that intrauterine growth restriction followed by rapid post-natal growth is associated with high blood pressure. {W}e assessed the effect of early size and post-natal growth on blood pressure in a population from {W}est {A}frica, where fetal growth retardation and childhood malnutrition are common. {M}ethods {A} total of 1288 {S}enegalese subjects were followed from infancy to young adulthood (mean age 17.9 years). {A}dult systolic blood pressure ({SBP}) was regressed on infant and adult anthropometric characteristics. {R}esults {I}n unadjusted analyses, infant size was positively associated with adult {SBP} (1.1 +/- 03; {P} = 0.001 for weight; 0.7 +/- 0.3; {P} = 0.04 for length). {W}ith adjustment for current size, the regression coefficients for infant size were reversed (-0.2 +/- 0.3; {P} = 0.51 for weight; -0.3 +/- 0.3; {P} = 0.35 for length). {SBP} increased by 4.1 and 2.9 mm{H}g for 1 standard deviation ({SD}) increase in current weight or height, respectively. {N}o interaction between infant size and current size was found in the overall models ({P} = 0.11 for weight, {P} = 0.95 for height), but this term interacted with sex for weight effect. {A} negative interaction was found in males (-0.9 +/- 0.4; {P} = 0.02) but not in females (0.3 +/- 0.4; {P} = 0.46). {T}he association of current weight with {SBP} was stronger in lighter weight male infants. {C}onclusions {T}hese findings support the hypothesis that subjects who were small in early life and experienced enhanced post-natal growth have higher levels of {SBP}, even in low-income settings.}, keywords = {{B}lood pressure ; infant body size ; growth ; developing countries ; cohort study}, booktitle = {}, journal = {{I}nternational {J}ournal of {E}pidemiology}, volume = {38}, numero = {5}, pages = {1401--1410}, ISSN = {0300-5771}, year = {2009}, DOI = {10.1093/ije/dyp255}, URL = {https://www.documentation.ird.fr/hor/fdi:010048330}, }