Ndao Cheikh Tidiane auteur aut IRD Dumont Alexandre auteur aut IRD Fievet Marie-Nadine auteur aut IRD Doucouré Souleymane auteur aut IRD Gaye A. auteur aut IRD Le Hesran Jean-Yves auteur aut IRD text journalArticle eng text/pdf born digital access In tropical countries, malaria and hypertension are common diseases of pregnancy. They have physiopathologic similarities such as placental ischemia, endothelial dysfunction, and production of proinflammatory cytokines. Recent findings suggested their possible link. The authors conducted a case-control study to explore the relation between malaria and hypertension at Guediawaye, a hypoendemic malarial setting in Senegal. Cases were pregnant women admitted to the delivery unit for hypertension. Controls were pregnant women admitted for normal delivery, without any history of hypertension or proteinuria during the present pregnancy. Malarial infection was determined by placental tissue examination. From January to December 2002, 77 cases of gestational hypertension, 113 cases of preeclampsia, 59 cases of eclampsia, and 241 controls were enrolled. Placental malarial infection (PMI) was present in 14 cases (6.3%) and in 15 controls (6.2%). The prevalence of PMI was 4.6% for eclampsia, 4.0% for preeclampsia, and 11.6% for gestational hypertension. In multivariate analysis, PMI appeared to be an independent risk factor for gestational hypertension (adjusted odds ratio = 2.7, 95% confidence interval: 1.0, 7.6). The authors found an association between PMI and nonproteinuric hypertension in women living in a malaria-hypoendemic area. The exact significance of such relation should be clarified in further studies in different settings of malarial endemicity. specialized Africa hypertension malaria placenta pre-eclampsia pregnancy Senegal 052 170 7 847-853 2009 0002-9262 https://www.documentation.ird.fr/hor/fdi:010048226 10.1093/aje/kwp207 0002-9262 [F B010048226] https://www.documentation.ird.fr/hor/fdi:010048226 https://www.documentation.ird.fr/intranet/publi/2009/10/010048226.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2009-11-09 2017-08-23 fdi:010048226 fre