@article{fdi:010048226,
  title = {{P}lacental malarial infection as a risk factor for hypertensive disorders during pregnancy in {A}frica : a case-control study in an urban area of {S}enegal, {W}est {A}frica},
  author = {{N}dao, {C}heikh {T}idiane and {D}umont, {A}lexandre and {F}ievet, {M}arie-{N}adine and {D}oucour{\'e}, {S}ouleymane and {G}aye, {A}. and {L}e {H}esran, {J}ean-{Y}ves},
  editor = {},
  language = {{ENG}},
  abstract = {{I}n tropical countries, malaria and hypertension are common diseases of pregnancy. {T}hey have physiopathologic similarities such as placental ischemia, endothelial dysfunction, and production of proinflammatory cytokines. {R}ecent findings suggested their possible link. {T}he authors conducted a case-control study to explore the relation between malaria and hypertension at {G}uediawaye, a hypoendemic malarial setting in {S}enegal. {C}ases were pregnant women admitted to the delivery unit for hypertension. {C}ontrols were pregnant women admitted for normal delivery, without any history of hypertension or proteinuria during the present pregnancy. {M}alarial infection was determined by placental tissue examination. {F}rom {J}anuary to {D}ecember 2002, 77 cases of gestational hypertension, 113 cases of preeclampsia, 59 cases of eclampsia, and 241 controls were enrolled. {P}lacental malarial infection ({PMI}) was present in 14 cases (6.3%) and in 15 controls (6.2%). {T}he prevalence of {PMI} was 4.6% for eclampsia, 4.0% for preeclampsia, and 11.6% for gestational hypertension. {I}n multivariate analysis, {PMI} appeared to be an independent risk factor for gestational hypertension (adjusted odds ratio = 2.7, 95% confidence interval: 1.0, 7.6). {T}he authors found an association between {PMI} and nonproteinuric hypertension in women living in a malaria-hypoendemic area. {T}he exact significance of such relation should be clarified in further studies in different settings of malarial endemicity.},
  keywords = {{A}frica ; hypertension ; malaria ; placenta ; pre-eclampsia ; pregnancy ; {S}enegal},
  booktitle = {},
  journal = {{A}merican {J}ournal of {E}pidemiology},
  volume = {170},
  numero = {7},
  pages = {847--853},
  ISSN = {0002-9262},
  year = {2009},
  DOI = {10.1093/aje/kwp207},
  URL = {https://www.documentation.ird.fr/hor/fdi:010048226},
}