%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Ndiaye, H. D.
%A Toure-Kane, C.
%A Vidal, Nicole
%A Niama, F. R.
%A Niang-Diallo, P. A.
%A Dieye, T.
%A Gave-Diallo, A.
%A Wade, A. S.
%A Peeters, Martine
%A Mboup, S.
%T Surprisingly high prevalence of subtype C and specific HIV-1 subtype/CRF distribution in men having sex with men in Senegal
%D 2009
%L fdi:010048220
%G ENG
%J Jaids - Journal of Acquired Immune Deficiency Syndromes
%@ 1525-4135
%K HIV-1 diversity ; MSM ; Senegal ; subtype C
%M ISI:000270206500013
%N 2
%P 249-252
%U https://www.documentation.ird.fr/hor/fdi:010048220
%> https://www.documentation.ird.fr/intranet/publi/2009/10/010048220.pdf
%V 52
%W Horizon (IRD)
%X Background: Recent reports showed the high vulnerability for HIV infection of men who have sex with men (MSM) in Africa. Here, we report the HIV-1 variants that circulate among MSM in Senegal. Methods: HIV-1 subtype/circulating recombinant form (CRF) was determined in an 1800-base pair fragment of pol for 70 HIV-1-positive samples from MSM. Phylogenetic trees were constructed using the neighbor-joining method with CLUSTALX. Similarity and bootstrap plots were then done for recombination analysis. The maximum likelihood approach was used for the identification of transmission clusters. Results: Sixty-seven samples (95%) were from Senegalese MSM, 90% unmarried with a median age of 30 years. Fifty-five MSM had regular male partners, but 39 of 70 had also a regular female partner. The overall subtype/CRF distribution was as follows: 28 C (40%), 17 CRF02_AG (24.3%), 13 B (18.6%), 6 G (8.6%), 3 CRF09_cpx (4.3%), and 3 (4.3%) unique recombinants. In addition, 47 sequences (67.15%) were segregated into 15 transmission clusters. Conclusions: These variants circulate also among the general population or female sex workers, but the proportions are significantly different. Despite the massive stigma, the majority (80%) of MSM recognized having sex with women and could serve as a bridge for intermixing of HIV-1 variants between high-risk men and low-risk women.
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