@article{fdi:010048197,
  title = {{H}uman {I}g{G} response to a salivary peptide, g{SG}6-{PI}, as a new immuno-epidemiological tool for evaluating low-level exposure to {A}nopheles bites},
  author = {{P}oinsignon, {A}nne and {C}orn{\'e}lie, {S}ylvie and {B}â, {F}atou and {B}oulanger, {D}enis and {S}ow, {C}heikh and {R}ossignol, {M}arie and {S}okhna, {C}heikh and {C}iss{\'e}, {B}adara and {S}imondon, {F}ran{\c{c}}ois and {R}emou{\'e}, {F}ranck},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {H}uman populations exposed to low malaria transmission present particular severe risks of malaria morbidity and mortality. {I}n addition, in a context of low-level exposure to {A}nopheles vector, conventional entomological methods used for sampling {A}nopheles populations are insufficiently sensitive and probably under-estimate the real risk of malaria transmission. {T}he evaluation of antibody ({A}b) responses to arthropod salivary proteins constitutes a novel tool for estimating exposure level to insect bites. {I}n the case of malaria, a recent study has shown that human {I}g{G} responses to the g{SG}6-{PI} peptide represented a specific biomarker of exposure to {A}nopheles gambiae bites. {T}he objective of this study was to investigate if this biomarker can be used to estimate low-level exposure of individuals to {A}nopheles vector. {M}ethods: {T}he {I}g{G} {A}b level to g{SG}6-{PI} was evaluated at the peak and at the end of the {A}n. gambiae exposure season in children living in {S}enegalese villages, where the {A}nopheles density was estimated to be very low by classical entomological trapping but where malaria transmission occurred during the studied season. {R}esults: {S}pecific {I}g{G} responses to g{SG}6-{PI} were observed in children exposed to very low-level of {A}nopheles bites. {I}n addition, a significant increase in the specific {I}g{G} {A}b level was observed during the {A}nopheles exposure season whereas classical entomological data have reported very few or no {A}nopheles during the studied period. {F}urthermore, this biomarker may also be applicable to evaluate the heterogeneity of individual exposure. {C}onclusion: {T}he results strengthen the hypothesis that the evaluation of {I}g{G} responses to g{SG}6-{PI} during the season of exposure could reflect the real human contact with anthropophilic {A}nopheles and suggest that this biomarker of low exposure could be used at the individual level. {T}his promising immuno-epidemiological marker could represent a useful tool to assess the risk to very low exposure to malaria vectors as observed in seasonal, urban, altitude or travellers contexts. {I}n addition, this biomarker could be used for the surveillance survey after applying anti-vector strategy.},
  keywords = {},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {8},
  numero = {},
  pages = {198 [8 ]},
  ISSN = {1475-2875},
  year = {2009},
  DOI = {10.1186/1475-2875-8-198},
  URL = {https://www.documentation.ird.fr/hor/fdi:010048197},
}