%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Vidal, Nicole
%A Bazepeo, S. E.
%A Mulanga, C.
%A Delaporte, Eric
%A Peeters, Martine
%T Genetic characterization of eight full-length HIV type 1 genomes from the democratic republic of Congo (DRC) reveal a new subsubtype, A5, in the A radiation that predominates in the recombinant structure of CRF26_A5U
%D 2009
%L fdi:010048169
%G ENG
%J Aids Research and Human Retroviruses
%@ 0889-2229
%M ISI:000268937300012
%N 8
%P 823-832
%R 10.1089/aid.2008.0283
%U https://www.documentation.ird.fr/hor/fdi:010048169
%> https://www.documentation.ird.fr/intranet/publi/2009/09/010048169.pdf
%V 25
%W Horizon (IRD)
%X In this study, we characterized HIV-1 strains from the Democratic Republic of Congo (DRC), previously described as divergent subtype A (n = 1,97CD.KMST91) or untypable (n = 7) in the V3-V5 env region. Four strains had the same structure over the entire genome, including alternating fragments of a new subsubtype, A5, within the subtype A radiation and fragments that remain unclassified. Therefore, the cluster of new viruses represents a new circulating recombinant, CRF26_A5U. Three additional strains were unique recombinants with the newly described CRF26_A5U and subtype C. Finally, the nearly full-length sequence of 97CD.KMST91 showed that this strain also consisted of alternating fragments of a divergent subtype A lineage and unclassified fragments, although different from previously reported A and U sequences. The high genetic distances among the different CRF26-A5U strains suggest their longstanding presence in the DRC.
%$ 052