@article{fdi:010046485,
  title = {{I}dentification of {A}polipoprotein {C}-{III} as a potential plasmatic biomarker associated with the resolution of hepatitis {C} virus infection},
  author = {{M}olina, {S}. and {M}iss{\'e}, {D}oroth{\'e}e and {R}oche, {S}. and {B}adiou, {S}. and {C}ristol, {J}. {P}. and {B}onfils, {C}. and {D}ierick, {J}. {F}. and {V}eas, {F}rancisco and {L}evayer, {T}. and {B}onnefont {R}ousselot, {D}. and {M}aurel, {P}. and {C}oste, {J}. and {F}ournier {W}irth, {C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{U}nderstanding the virus-host interactions that lead to approximately 20% of patients with acute {H}epatitis {C} {V}irus ({HCV}) infection to viral clearance is probably a key towards the development of more effective treatment and prevention strategies. {A}cute hepatitis {C} infection is usually asymptomatic and therefore rarely diagnosed. {N}evertheless, {HCV} nucleic acid testing carried out on all blood donations detects donors who have resolved their {HCV} infection after seroconversion. {H}ere we have used {SELDI}-{TOF}-{MS} technology to compare, at a proteomic level, plasma samples respectively from donors with {HCV} clearance, from donors with chronic {HCV} infection and from unexposed healthy donors (n=15 per group). {A} candidate marker of about 9.4 k{D}a was detected as differentially expressed in the three groups. {A}fter purification we identified by nano{LC}-{Q}-{TOF}-{MS}/{MS} this candidate marker as {A}polipoprotein {C}-{III} ({A}po{C}-{III}). {T}he identification was confirmed by western blot analysis. {L}evels of {A}po{C}-{I}ll were then determined in the 45 plasma samples by immunoturbidimetric assay. {A}po{C}-{III} was found to be higher in donors who had resolved their {HCV} infection than in donors with chronic infection, results which were consistent with {SELDI}-{TOF}-{MS} data. {A}po{C}-{III} is the first reported candidate biomarker in plasma associated with the spontaneous resolution of {HCV} infection.},
  keywords = {{A}po{C} {III} ; biomarker ; {HCV} clearance ; plasma ; {SELDI} {TOF} {MS}},
  booktitle = {},
  journal = {{P}roteomics {C}linical {A}pplications},
  volume = {2},
  numero = {5},
  pages = {751--761},
  ISSN = {1862-8346},
  year = {2008},
  DOI = {10.1002/prca.200800020},
  URL = {https://www.documentation.ird.fr/hor/fdi:010046485},
}