Maether M. P. auteur aut IRD Desoubzdanne D. auteur aut IRD Izquierdo A. auteur aut IRD Guieu V. auteur aut IRD Maturano M. auteur aut IRD Andre-Barres C. auteur aut IRD Valentin A. auteur aut IRD Jullian Valérie auteur aut IRD Chevalley Séverine auteur aut IRD Maynadier M. auteur aut IRD Vial H. auteur aut IRD Payrastre C. auteur aut IRD text journalArticle eng text/pdf born digital access Several streptocyanine dyes were synthesized that contain polymethine chains of varying length. Their in vitro antimalarial activities were evaluated against the virulent P. falciparum parasite. In addition to the influence of polymethine chain length, the effects of structural modifications at nitrogen end groups, para substitution of the phenyl groups, and counter-anions were studied. The most potent antimalarial activities were found for heptacarbon chain streptocyanines, with an IC50 value of 60 nM. Interestingly, most of the compounds were less cytotoxic toward the mammalian cells tested. The best selective toxicity profiles were found for pentacarbon chain streptocyanines, which have a good in vitro specificity index. specialized antiprotozoal agents cyanine cytotoxicity malaria Plasmodium falciparum 076 052 4 8 1327-1332 2009 1860-7179 https://www.documentation.ird.fr/hor/fdi:010046280 10.1002/cmdc.200900051 1860-7179 [F B010046280] https://www.documentation.ird.fr/hor/fdi:010046280 https://www.documentation.ird.fr/intranet/publi/2009/08/010046280.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2009-09-01 2017-08-23 fdi:010046280 fre