@article{fdi:010046280,
  title = {{S}ynthesis and antimalarial properties of streptocyanine dyes},
  author = {{M}aether, {M}. {P}. and {D}esoubzdanne, {D}. and {I}zquierdo, {A}. and {G}uieu, {V}. and {M}aturano, {M}. and {A}ndre-{B}arres, {C}. and {V}alentin, {A}. and {J}ullian, {V}al{\'e}rie and {C}hevalley, {S}{\'e}verine and {M}aynadier, {M}. and {V}ial, {H}. and {P}ayrastre, {C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{S}everal streptocyanine dyes were synthesized that contain polymethine chains of varying length. {T}heir in vitro antimalarial activities were evaluated against the virulent {P}. falciparum parasite. {I}n addition to the influence of polymethine chain length, the effects of structural modifications at nitrogen end groups, para substitution of the phenyl groups, and counter-anions were studied. {T}he most potent antimalarial activities were found for heptacarbon chain streptocyanines, with an {IC}50 value of 60 n{M}. {I}nterestingly, most of the compounds were less cytotoxic toward the mammalian cells tested. {T}he best selective toxicity profiles were found for pentacarbon chain streptocyanines, which have a good in vitro specificity index.},
  keywords = {antiprotozoal agents ; cyanine ; cytotoxicity ; malaria ; {P}lasmodium ; falciparum},
  booktitle = {},
  journal = {{C}hemmedchem},
  volume = {4},
  numero = {8},
  pages = {1327--1332},
  ISSN = {1860-7179},
  year = {2009},
  DOI = {10.1002/cmdc.200900051},
  URL = {https://www.documentation.ird.fr/hor/fdi:010046280},
}