@article{fdi:010046274,
  title = {{E}pilepsy in onchocerciasis endemic areas : systematic review and meta-analysis of population-based surveys},
  author = {{P}ion, {S}{\'e}bastien and {K}aiser, {C}. and {B}outros-{T}oni, {F}. and {C}ournil, {A}mandine and {T}aylor, {M}. {M}. and {M}eredith, {S}. {E}. {O}. and {S}tufe, {A}. and {B}ertocchi, {I}. and {K}ipp, {W}. and {P}reux, {P}. {M}. and {B}oussinesq, {M}ichel},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjective: {W}e sought to evaluate the relationship between onchocerciasis prevalence and that of epilepsy using available data collected at community level. {D}esign: {W}e conducted a systematic review and meta-regression of available data. {D}ata {S}ources: {E}lectronic and paper records on subject area ever produced up to {F}ebruary 2008. {R}eview {M}ethods: {W}e searched for population-based studies reporting on the prevalence of epilepsy in communities for which onchocerciasis prevalence was available or could be estimated. {T}wo authors independently assessed eligibility and study quality and extracted data. {T}he estimation of point prevalence of onchocerciasis was standardized across studies using appropriate correction factors. {V}ariation in epilepsy prevalence was then analyzed as a function of onchocerciasis endemicity using random-effect logistic models. {R}esults: {E}ight studies from west ( {B}enin and {N}igeria), central ( {C}ameroon and {C}entral {A}frican {R}epublic) and east {A}frica ( {U}ganda, {T}anzania and {B}urundi) met the criteria for inclusion and analysis. {N}inety-one communities with a total population of 79,270 individuals screened for epilepsy were included in the analysis. {T}he prevalence of epilepsy ranged from 0 to 8.7% whereas that of onchocerciasis ranged from 5.2 to 100%. {V}ariation in epilepsy prevalence was consistent with a logistic function of onchocerciasis prevalence, with epilepsy prevalence being increased, on average, by 0.4% for each 10% increase in onchocerciasis prevalence. {C}onclusion: {T}hese results give further evidence that onchocerciasis is associated with epilepsy and that the disease burden of onchocerciasis might have to be re-estimated by taking into account this relationship.},
  keywords = {},
  booktitle = {},
  journal = {{P}los {N}eglected {T}ropical {D}iseases},
  volume = {3},
  numero = {6},
  pages = {e461},
  ISSN = {1935-2735},
  year = {2009},
  DOI = {10.1371/journal.pntd.0000461},
  URL = {https://www.documentation.ird.fr/hor/fdi:010046274},
}