@article{fdi:010046256,
  title = {{G}enetic specificity and potential for local adaptation between dengue viruses and mosquito vectors},
  author = {{L}ambrechts, {L}ouis and {C}hevillon, {C}hristine and {A}lbright, {R}.{G}. and {T}haisomboonsuk, {B}. and {R}ichardson, {J}.{H}. and {J}arman, {R}.{G}. and {S}cott, {T}.{W}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {S}everal observations support the hypothesis that vector-driven selection plays an important role in shaping dengue virus ({DENV}) genetic diversity. {C}lustering of {DENV} genetic diversity at a particular location may reflect underlying genetic structure of vector populations, which combined with specific vector genotype x virus genotype ({G} x {G}) interactions may promote adaptation of viral lineages to local mosquito vector genotypes. {A}lthough spatial structure of vector polymorphism at neutral genetic loci is well-documented, existence of {G} x {G} interactions between mosquito and virus genotypes has not been formally demonstrated in natural populations. {H}ere we measure {G} x {G} interactions in a system representative of a natural situation in {T}hailand by challenging three isofemale families from field-derived {A}edes aegypti with three contemporaneous low-passage isolates of {DENV}-1. {R}esults: {A}mong indices of vector competence examined, the proportion of mosquitoes with a midgut infection, viral {RNA} concentration in the body, and quantity of virus disseminated to the head/legs (but not the proportion of infected mosquitoes with a disseminated infection) strongly depended on the specific combinations of isofemale families and viral isolates, demonstrating significant {G} x {G} interactions. {C}onclusion: {E}vidence for genetic specificity of interactions in our simple experimental design indicates that vector competence of {A}e. aegypti for {DENV} is likely governed to a large extent by {G} x {G} interactions in genetically diverse, natural populations. {T}his result challenges the general relevance of conclusions from laboratory systems that consist of a single combination of mosquito and {DENV} genotypes. {C}ombined with earlier evidence for fine-scale genetic structure of natural {A}e. aegypti populations, our finding indicates that the necessary conditions for local {DENV} adaptation to mosquito vectors are met.},
  keywords = {},
  booktitle = {},
  journal = {{B}mc {E}volutionary {B}iology},
  volume = {9},
  numero = {},
  pages = {160},
  ISSN = {1471-2148},
  year = {2009},
  DOI = {10.1186/1471-2148-9-160},
  URL = {https://www.documentation.ird.fr/hor/fdi:010046256},
}