Subileau M. auteur aut IRD Barnabé Christian auteur aut IRD Douzery E. J. P. auteur aut IRD Diosque P. auteur aut IRD Tibayrenc Michel auteur aut IRD text journalArticle eng text/pdf born digital access Natural populations of Trypanosoma cruzi are structured into five genetic lineages, T cruzi I and T. cruzi II a to e, as the result of clonal evolution with rare genetic recombination events. To explore more in depth these phenomenons, a multigene sequencing approach was used, for the first time in the case of T. cruzi. Three nuclear loci and a maxicircle locus were sequenced on 18 T. cruzi stocks. Sequences were used to build phylogenetic trees from each locus and from concatenated sequences of all loci. The data confirmed the hybrid origin of DTUs IId and IIe, as the result of an ancient genetic recombination between strains pertaining to IIb and IIc. The data confirmed also a hybrid origin of DTUs IIa and IIc. Contrary to previous reports, we failed to detect mosaic genes. The phylogenetic relationship between DTUs and the respective roles of recombination and selection were tested. specialized Tryponosoma cruzi Kinetoplastidae Multigene sequencing Phylogeny Hybrid origins Recombination Clonality Discrete typing units 052 122 4 328-337 2009 0014-4894 https://www.documentation.ird.fr/hor/fdi:010046204 10.1016/j.exppara.2009.04.008 0014-4894 [F B010046204] https://www.documentation.ird.fr/hor/fdi:010046204 https://www.documentation.ird.fr/intranet/publi/2009/07/010046204.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2009-07-24 2017-08-23 fdi:010046204 fre